Hexosaminidase A 抗体 (AA 135-179)
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Quick Overview for Hexosaminidase A 抗体 (AA 135-179) (ABIN7870538)
抗原
See all Hexosaminidase A (HEXA) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 135-179
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原理
- Hexosaminidase A Antibody / HEXA
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids A135-H179) was used as the immunogen for the Hexosaminidase A antibody.
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亚型
- IgG
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anti-Hexosaminidase A (HEXA) (AA 142-170), (N-Term) antibody
HEXA 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20977 unconjugated
anti-Hexosaminidase A (HEXA) (AA 318-529) antibodyHEXA 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase A (HEXA) (AA 1-529) antibodyHEXA 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3D1 unconjugated
anti-Hexosaminidase A (HEXA) antibodyHEXA 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 3F10 unconjugated
anti-Hexosaminidase A (HEXA) (Internal Region) antibodyHEXA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase A (HEXA) (AA 1-529) antibodyHEXA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D1 unconjugated
anti-Hexosaminidase A (HEXA) antibodyHEXA 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS 宿主: 小鼠 Monoclonal unconjugated
anti-Hexosaminidase A (HEXA) (AA 319-528) antibodyHEXA 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase A (HEXA) (AA 89-529) antibodyHEXA 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase A (HEXA) (AA 315-343) antibodyHEXA 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20993 unconjugated
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应用备注
- Optimal dilution of the Hexosaminidase A antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Hexosaminidase A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Hexosaminidase A (HEXA)
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别名
- Hexosaminidase A
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背景
- HEXA, hexosaminidase A (alpha polypeptide), is an enzyme that in humans is encoded by the HEXA gene. Hexosaminidase A and the cofactor GM2 activator protein catalyze the degradation of the GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines. The HEXA gene encodes the alpha subunit of hexosaminidase A , a lysosomal enzyme involved in the breakdown of gangliosides. The HEXA gene is mapped on 15q23. Even though the alpha and beta subunits of hexosaminidase A can both cleave GalNAc residues, only the alpha subunit is able to hydrolyze GM2 gangliosides. The alpha subunit contains a key residue, Arg-424, which is essential for binding the N-acetyl-neuramanic residue of GM2 gangliosides. Chimeric constructs were expressed in HeLa cells and selected constructs were produced in the baculovirus expression system to determine their ability to degrade GM2 ganglioside in the presence of GM2 activator protein. Their results allowed them to define 2 noncontiguous sequences in the alpha subunit (amino acids 1-191 and 403-529) which, when substituted into analogous positions in the beta subunit, conferred activity against the sulfated substrate.
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UniProt
- P06865
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途径
- Sensory Perception of Sound, Glycosaminoglycan Metabolic Process
抗原
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