MMP20 抗体 (AA 124-405)
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Quick Overview for MMP20 抗体 (AA 124-405) (ABIN7870366)
抗原
See all MMP20 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 124-405
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原理
- MMP20 Antibody / Matrix metalloproteinase 20
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human MMP20 recombinant protein (Position: Y124-K405) was used as the immunogen for the MMP20 antibody.
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亚型
- IgG
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anti-Matrix Metalloproteinase 20 (MMP20) (AA 51-150) antibody
MMP20 适用: 人, 小鼠, 猴 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metalloproteinase 20 (MMP20) (AA 137-398) antibodyMMP20 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metalloproteinase 20 (MMP20) (AA 1-483) antibodyMMP20 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metalloproteinase 20 (MMP20) (AA 233-262) antibodyMMP20 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB2037-2038 unconjugated
anti-Matrix Metalloproteinase 20 (MMP20) (AA 401-483) antibodyMMP20 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metalloproteinase 20 (MMP20) (AA 1-483) antibodyMMP20 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Matrix Metalloproteinase 20 (MMP20) (AA 396-445) antibodyMMP20 适用: 人, 小鼠, Pig, 犬, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metalloproteinase 20 (MMP20) (AA 399-428), (C-Term) antibodyMMP20 适用: 人 WB 宿主: 兔 Polyclonal RB34032 unconjugated
anti-Matrix Metalloproteinase 20 (MMP20) (Middle Region) antibodyMMP20 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metalloproteinase 20 (MMP20) (Middle Region) antibodyMMP20 适用: 人, 小鼠, 大鼠, Pig, Cow, 犬, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the MMP20 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MMP20 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MMP20 (Matrix Metalloproteinase 20 (MMP20))
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别名
- MMP20
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背景
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MMP20 antibody detects Matrix metalloproteinase-20, an extracellular endopeptidase that degrades enamel matrix proteins during tooth development. The UniProt recommended name is Matrix metalloproteinase-20 (MMP20). Also known as enamelysin, this enzyme belongs to the matrix metalloproteinase family responsible for remodeling extracellular matrix components during morphogenesis and tissue repair.
Functionally, MMP20 antibody identifies a 483-amino-acid secreted zinc-dependent protease synthesized as a zymogen that is activated by propeptide cleavage. MMP20 is specifically expressed in ameloblasts and odontoblasts, where it cleaves amelogenin, ameloblastin, and enamelin to enable proper enamel mineralization and organization.
The MMP20 gene is located on chromosome 11q22.2 and exhibits tissue-specific expression limited primarily to developing teeth. Its enzymatic activity contributes to normal enamel formation and maturation during odontogenesis.
Pathologically, mutations in MMP20 cause autosomal recessive amelogenesis imperfecta, a disorder characterized by defective enamel formation and tooth fragility. Altered MMP20 expression has also been implicated in oral cancer and tissue invasion. Research using MMP20 antibody supports studies in dental biology, extracellular matrix remodeling, and developmental biochemistry.
MMP20 antibody is validated for western blotting, immunohistochemistry, and ELISA to detect matrix-degrading enzymes. NSJ Bioreagents provides MMP20 antibody reagents optimized for dental development, tissue remodeling, and protease regulation research.
Structurally, Matrix metalloproteinase-20 features a catalytic zinc-binding domain and a hemopexin-like domain responsible for substrate recognition. This antibody enables investigation of MMP20's function in enamel formation and extracellular matrix turnover. -
UniProt
- O60882
抗原
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