ANKRD1 抗体 (AA 120-319)
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Quick Overview for ANKRD1 抗体 (AA 120-319) (ABIN7870310)
抗原
See all ANKRD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 120-319
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原理
- ANKRD1 Antibody / Ankyrin repeat domain-containing protein 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human ANKRD1 recombinant protein (Position: D120-F319) was used as the immunogen for the ANKRD1 antibody.
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亚型
- IgG
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anti-Ankyrin Repeat Domain 1 (Cardiac Muscle) (ANKRD1) (AA 1-319) antibody
ANKRD1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ankyrin Repeat Domain 1 (Cardiac Muscle) (ANKRD1) (AA 185-319) antibodyANKRD1 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ankyrin Repeat Domain 1 (Cardiac Muscle) (ANKRD1) (AA 1-130) antibodyANKRD1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ankyrin Repeat Domain 1 (Cardiac Muscle) (ANKRD1) (AA 1-319) antibodyANKRD1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ankyrin Repeat Domain 1 (Cardiac Muscle) (ANKRD1) (AA 5-279) antibodyANKRD1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ankyrin Repeat Domain 1 (Cardiac Muscle) (ANKRD1) (AA 6-291) antibodyANKRD1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ankyrin Repeat Domain 1 (Cardiac Muscle) (ANKRD1) (AA 12-34) antibodyANKRD1 适用: 人 WB 宿主: 兔 Polyclonal RB55317 unconjugated
anti-Ankyrin Repeat Domain 1 (Cardiac Muscle) (ANKRD1) (C-Term) antibodyANKRD1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ankyrin Repeat Domain 1 (Cardiac Muscle) (ANKRD1) antibodyANKRD1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ankyrin Repeat Domain 1 (Cardiac Muscle) (ANKRD1) (AA 231-280) antibodyANKRD1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the ANKRD1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the ANKRD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- ANKRD1 (Ankyrin Repeat Domain 1 (Cardiac Muscle) (ANKRD1))
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别名
- ANKRD1
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背景
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ANKRD1 antibody detects Ankyrin repeat domain-containing protein 1, encoded by the ANKRD1 gene. Ankyrin repeat domain-containing protein 1 is a transcriptional cofactor and stress-responsive protein that contributes to cardiac muscle biology, mechanical signaling, and gene regulation. ANKRD1 antibody provides researchers with a highly specific reagent for studying cardiomyocyte adaptation, hypertrophy, and muscle stress responses.
Ankyrin repeat domain-containing protein 1 belongs to the CARP (cardiac ankyrin repeat protein) family. Research using ANKRD1 antibody has shown that it is predominantly expressed in heart and skeletal muscle, where it localizes to the sarcomere, especially the I-band. Its ankyrin repeat domains allow it to interact with titin, myopalladin, and transcriptional regulators, linking mechanical stretch sensing to gene expression programs. This dual localization to sarcomeres and nuclei makes it an important signaling intermediary.
Studies with ANKRD1 antibody have revealed that its expression is induced by hypertrophic stress, hypoxia, and injury. In cardiomyocytes, ANKRD1 acts as both a structural stabilizer and a regulator of stress-induced transcriptional pathways. Elevated expression has been observed in dilated and hypertrophic cardiomyopathy, suggesting its potential role as a biomarker of heart disease.
Dysregulation of ANKRD1 has also been associated with muscular disorders and cancer. Research using ANKRD1 antibody has demonstrated that mutations in ANKRD1 contribute to congenital cardiomyopathy, while altered expression in tumors influences cell proliferation and invasion. Its pleiotropic functions in muscle and non-muscle tissues highlight its importance across biology.
ANKRD1 antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies expression in cardiac and skeletal tissue, immunohistochemistry highlights localization in diseased myocardium, and immunofluorescence demonstrates sarcomeric localization in cardiomyocytes. These methods make ANKRD1 antibody indispensable for cardiac biology research.
By supplying validated ANKRD1 antibody reagents, NSJ Bioreagents supports studies into sarcomere biology, transcriptional regulation, and disease. Detection of Ankyrin repeat domain-containing protein 1 provides researchers with insight into how cardiomyocytes adapt to stress and maintain function. -
UniProt
- Q15327
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途径
- Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Response to DNA Damage Stimulus
抗原
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