TCTN1 抗体 (AA 118-470)
The 兔 多克隆 anti-TCTN1 antibody (ABIN7870264) specifically detects TCTN1 in WB, ELISA, IHC 和 FACS.
The antibody is reactive with 大鼠, 人 和 小鼠 samples.
产品编号 ABIN7870264
发货至:
中国
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Quick Overview for TCTN1 抗体 (AA 118-470) (ABIN7870264)
抗原
See all TCTN1 抗体
TCTN1
(Tectonic Family Member 1 (TCTN1))
适用
大鼠, 人, 小鼠
宿主
兔
克隆类型
多克隆
标记
This TCTN1 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
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抗原表位
- AA 118-470
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原理
- TCTN1 Antibody / Tectonic 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TCTN1 recombinant protein (Position: Q118-Y470) was used as the immunogen for the TCTN1 antibody.
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亚型
- IgG
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anti-Tectonic Family Member 1 (TCTN1) (N-Term) antibody
TCTN1 适用: 大鼠, 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tectonic Family Member 1 (TCTN1) (N-Term) antibodyTCTN1 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TCTN1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TCTN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TCTN1 (Tectonic Family Member 1 (TCTN1))
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别名
- TCTN1
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背景
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TCTN1 antibody detects Tectonic-1, a membrane-associated protein essential for ciliogenesis and Hedgehog signaling. The UniProt recommended name is Tectonic-1 (TCTN1). This protein localizes to the ciliary transition zone, where it participates in the formation and maintenance of the primary cilium, a sensory organelle crucial for signal transduction during embryonic development and tissue patterning.
Functionally, TCTN1 antibody identifies a 765-amino-acid protein that interacts with other tectonic complex components such as TCTN2, TCTN3, and MKS1. TCTN1 regulates protein trafficking into the cilium and ensures the proper localization of signaling receptors, including those of the Hedgehog pathway. It is indispensable for normal morphogenesis and neural tube patterning.
The TCTN1 gene is located on chromosome 12q24.11 and is expressed in ciliated cells throughout various tissues, including brain, kidney, and retina. Its activity maintains ciliary structure and mediates signal coordination during development and organogenesis.
Pathologically, mutations in TCTN1 lead to ciliopathies such as Joubert and Meckel-Gruber syndromes, which are characterized by developmental defects in the brain, kidneys, and eyes. Dysfunction of TCTN1 disrupts ciliary signaling, resulting in structural malformations and impaired embryonic patterning. Research using TCTN1 antibody supports studies in ciliary biology, developmental signaling, and ciliopathy mechanisms.
TCTN1 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect ciliary transition zone proteins. NSJ Bioreagents provides TCTN1 antibody reagents optimized for developmental biology, signal transduction, and structural cell biology research.
Structurally, Tectonic-1 contains multiple coiled-coil regions and a C-terminal transmembrane domain that anchor it to the ciliary membrane. This antibody enables investigation of TCTN1's function in ciliogenesis and Hedgehog pathway regulation. -
UniProt
- Q2MV58
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途径
- Tube Formation
抗原
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