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TPSAB1 抗体 (AA 115-233)

The 小鼠 单克隆 anti-TPSAB1 antibody is suitable to detect TPSAB1 in samples from 人. It has been validated for IHC (p).
产品编号 ABIN7870206
发货至: 中国
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Quick Overview for TPSAB1 抗体 (AA 115-233) (ABIN7870206)

抗原

See all TPSAB1 抗体
TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

适用

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宿主

  • 73
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小鼠

克隆类型

  • 75
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单克隆

标记

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This TPSAB1 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

TPSAB1-1961
  • 抗原表位

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    AA 115-233

    原理

    TPSAB1 Antibody / Mast Cell Tryptase

    纯化方法

    Protein G affinity chromatography

    免疫原

    A portion of amino acids 115-233 from the human protein was used as the immunogen for this TPSAB1 antibody.

    亚型

    IgG1, kappa
  • 应用备注

    Optimal dilution of the TPSAB1 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store the TPSAB1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

    别名

    TPSAB1

    背景

    Tryptases comprise a family of trypsin-like serine proteases (peptidase family S1). Tryptases are stored in mast cell secretory granules and basophils. Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Tryptases are released into the extracellular environment and are resistant to all known endogenous proteinase inhibitors. This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis.

    UniProt

    Q15661
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