TMEM232 抗体 (AA 114-598)
The 兔 多克隆 anti-TMEM232 antibody is suitable to detect TMEM232 in samples from 人, 小鼠 和 大鼠. It has been validated for WB, ELISA, ICC, IF 和 IHC.
产品编号 ABIN7870194
发货至:
中国
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Quick Overview for TMEM232 抗体 (AA 114-598) (ABIN7870194)
抗原
TMEM232
(Transmembrane Protein 232 (TMEM232))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This TMEM232 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC)
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抗原表位
- AA 114-598
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原理
- TMEM232 Antibody / Transmembrane protein 232
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TMEM232 recombinant protein (Position: D114-H598) was used as the immunogen for the TMEM232 antibody.
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亚型
- IgG
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anti-Transmembrane Protein 232 (TMEM232) (N-Term) antibody
TMEM232 适用: 人, Cow, 犬, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TMEM232 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TMEM232 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TMEM232 (Transmembrane Protein 232 (TMEM232))
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别名
- TMEM232
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背景
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TMEM232 antibody recognizes Transmembrane protein 232, an integral membrane protein encoded by the TMEM232 gene on chromosome 5q22.1. TMEM232 is predicted to contain multiple transmembrane domains and is primarily localized to the plasma membrane and endomembrane compartments. Although not yet fully characterized, bioinformatic and transcriptomic studies indicate that TMEM232 may play roles in cellular signaling, immune regulation, and epithelial differentiation. Expression analysis shows enrichment in lung, skin, and immune cells, suggesting a function in barrier tissues and inflammatory response modulation.
Structurally, TMEM232 contains hydrophobic alpha-helical domains typical of multipass membrane proteins, along with cytoplasmic loops that may participate in protein-protein interactions and intracellular signaling. The exact ligand or binding partners of TMEM232 remain under investigation, but functional genomics screens have implicated it in immune homeostasis and allergic disease susceptibility. Variants in the TMEM232 gene have been associated with atopic dermatitis and asthma, supporting its potential role in epithelial barrier integrity and immune response control.
TMEM232 expression appears to be regulated by inflammatory cytokines such as IL-4 and IL-13, consistent with its link to type 2 immune responses. It may contribute to the regulation of keratinocyte differentiation and tight junction assembly in epithelial tissues. In immune cells, TMEM232 has been detected in macrophages and lymphocytes, where it could participate in cell signaling pathways that mediate cytokine production and cell adhesion. Structural modeling predicts that TMEM232 may act as a membrane anchor for signaling complexes, similar to other poorly characterized transmembrane adaptors.
From a clinical perspective, genome-wide association studies (GWAS) have repeatedly identified polymorphisms in TMEM232 associated with allergic rhinitis, atopy, and asthma across multiple populations. The gene's proximity to cytokine regulatory regions and its expression pattern in airway epithelial cells support a role in respiratory immune function. Further studies suggest TMEM232 could modulate epithelial repair following inflammation or injury. Dysregulation of TMEM232 expression may contribute to chronic inflammatory diseases of the skin and respiratory tract.
Immunohistochemical analysis using TMEM232 antibody shows membrane localization in airway epithelium, keratinocytes, and lymphoid tissue. The antibody is useful for characterizing transmembrane signaling proteins and identifying novel immune regulatory pathways. TMEM232 antibody from NSJ Bioreagents provides a valuable tool for research into epithelial biology, asthma genetics, and inflammatory signaling mechanisms. -
UniProt
- C9JQI7
抗原
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