HTRA3 抗体 (AA 112-144)
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北京 101111
Quick Overview for HTRA3 抗体 (AA 112-144) (ABIN7870129)
抗原
See all HTRA3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 112-144
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原理
- HtrA3 Antibody
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纯化方法
- Purified
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免疫原
- A portion of amino acids 112-144 from the human protein was used as the immunogen for the HtrA3 antibody.
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亚型
- Ig Fraction
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anti-HtrA Serine Peptidase 3 (HTRA3) (AA 112-144), (N-Term) antibody
HTRA3 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2322 unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) (AA 344-453) antibodyHTRA3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F2 unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) antibodyHTRA3 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) (AA 214-453) antibodyHTRA3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) (AA 334-453) antibodyHTRA3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) (AA 330-362), (C-Term) antibodyHTRA3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) (Middle Region) antibodyHTRA3 适用: 人, 大鼠, 小鼠, 豚鼠, 犬, 马 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- The stated application concentrations are suggested starting points. Titration of the HtrA3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the HtrA3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- HTRA3 (HtrA Serine Peptidase 3 (HTRA3))
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别名
- HtrA3
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背景
- Insulin-like growth factors (IGFs) stimulate the proliferation and differentiation of a vast number of cell types. The action of the growth factors is mediated and controlled by a complex system of components, including several proteases that cleave the IGF-Binding Proteins. HtrA1 is a 480 aa protein that contains an N-terminus homologous to MAC25 (IGFBP7) with a conserved Kazal-type serine protease inhibitor motif, as well as a C-terminal PDZ domain. Semiquantitative RT-PCR and immunoblot analyses showed an approximately 7-fold increase of PRSS11 in osteoarthritis cartilage compared with controls. HTRA2 is released from mitochondria and inhibits the function of XIAP by direct binding in a way similar to SMAC. Moreover, when overexpressed extramitochondrially, HTRA2 induced atypical cell death, which was neither accompanied by a significant increase in caspase activity nor inhibited by caspase inhibitors, including XIAP. A catalytically inactive mutant of HTRA2, however, did not induce cell death. Suzuki et al. (2001) concluded that HTRA2 is a SMAC-like inhibitor of IAP (inhibitor of apoptosis proteins) activity with a serine protease-dependent cell death-inducing activity.
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UniProt
- P83110
抗原
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