TBC1D4 抗体 (AA 1118-1298)
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北京 101111
Quick Overview for TBC1D4 抗体 (AA 1118-1298) (ABIN7870126)
抗原
See all TBC1D4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1118-1298
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原理
- TBC1D4 Antibody / AS160
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纯化方法
- Affinity purified
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免疫原
- An E. coli-derived human protein (amino acids K1118-P1298) was used as the immunogen for the TBC1D4 antibody.
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亚型
- IgG
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anti-TBC1 Domain Family, Member 4 (TBC1D4) (AA 574-712) antibody
TBC1D4 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 8A11A2 unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (AA 1-94) antibodyTBC1D4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (AA 172-201), (N-Term) antibodyTBC1D4 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB21034 unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (Internal Region) antibodyVerified TBC1D4 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) antibodyTBC1D4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB890 unconjugated Recombinant Antibody
anti-TBC1 Domain Family, Member 4 (TBC1D4) antibodyTBC1D4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (AA 1118-1298) antibodyTBC1D4 适用: 人 WB, ELISA, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (pThr642) antibodyTBC1D4 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (AA 1155-1204) antibodyTBC1D4 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (AA 200-250) antibodyTBC1D4 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TBC1D4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TBC1D4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))
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别名
- TBC1D4
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背景
- AS160 (Akt substrate of 160 kDa), which was originally known as TBC1 domain family member 4 (TBC1D4), is a Rab GTPase-activating protein that in humans is encoded by the TBC1D4 gene. This gene is a member of the Tre-2/BUB2/CDC16 domain family. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion.
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UniProt
- O60343
抗原
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