STRBP 抗体 (AA 110-617)
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北京 101111
Quick Overview for STRBP 抗体 (AA 110-617) (ABIN7870104)
抗原
See all STRBP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 110-617
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原理
- STRBP Antibody / Spermatid perinuclear RNA-binding protein
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human STRBP recombinant protein (Position: K110-R617) was used as the immunogen for the STRBP antibody.
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亚型
- IgG
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anti-Spermatid Perinuclear RNA Binding Protein (STRBP) (AA 201-500) antibody
STRBP 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Spermatid Perinuclear RNA Binding Protein (STRBP) (AA 40-190) antibodySTRBP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Spermatid Perinuclear RNA Binding Protein (STRBP) (AA 434-483) antibodySTRBP 适用: 人, 大鼠, 豚鼠, 兔, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Spermatid Perinuclear RNA Binding Protein (STRBP) (Middle Region) antibodySTRBP 适用: 人, 大鼠, 小鼠, 豚鼠, 兔, Cow, 犬, 马, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the STRBP antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the STRBP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- STRBP (Spermatid Perinuclear RNA Binding Protein (STRBP))
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别名
- STRBP
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背景
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The STRBP antibody targets Spermatid perinuclear RNA-binding protein, a multifunctional RNA- and microtubule-associated protein encoded by the STRBP gene. Spermatid perinuclear RNA-binding protein is involved in RNA transport, post-transcriptional regulation, and microtubule organization. It contributes to spermatogenesis, neuronal differentiation, and stress granule assembly. The STRBP antibody provides researchers with a versatile reagent for investigating RNA-binding protein networks and cytoskeletal coordination during differentiation and stress responses.
Spermatid perinuclear RNA-binding protein contains multiple double-stranded RNA-binding motifs (dsRBDs) and a leucine zipper domain that mediate RNA recognition and dimerization. It localizes to the cytoplasm and perinuclear region, where it associates with RNA granules and microtubules. The STRBP antibody supports detection of this localization, enabling studies of its role in mRNA transport and translational control. STRBP is particularly enriched in developing spermatids, where it participates in the storage and regulation of mRNAs required for sperm maturation.
Beyond reproductive function, Spermatid perinuclear RNA-binding protein is expressed in multiple tissues, including brain and heart, where it modulates RNA metabolism and cytoskeletal integrity. It binds to microtubule-associated complexes to stabilize RNA localization during cellular polarization. The STRBP antibody enables visualization of these interactions, providing insight into how STRBP integrates RNA processing with cytoskeletal rearrangement in differentiating cells.
STRBP also plays a role in stress granule formation during cellular stress, interacting with proteins such as Staufen and DDX3X to regulate mRNA triage and translation repression. The STRBP antibody supports studies of these dynamic processes, helping to elucidate the molecular mechanisms underlying mRNA storage and recovery following stress exposure. Dysregulation of STRBP has been linked to infertility, neurodevelopmental disorders, and altered stress responses.
The STRBP antibody is validated for western blotting, immunofluorescence, and immunohistochemistry, producing strong cytoplasmic and perinuclear staining consistent with its RNA granule localization. NSJ Bioreagents provides this antibody as a high-specificity reagent for reliable detection across molecular and cell biology studies. By supporting analysis of Spermatid perinuclear RNA-binding protein expression and function, the STRBP antibody advances understanding of RNA transport, cytoskeletal organization, and gene expression regulation in diverse biological contexts. -
UniProt
- Q96SI9
抗原
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