MMP13 抗体 (AA 110-476)
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Quick Overview for MMP13 抗体 (AA 110-476) (ABIN7870102)
抗原
See all MMP13 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 110-476
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原理
- Zebrafish Mmp13a Antibody / Interstitial collagenase
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Mmp13a recombinant protein (amino acids D110-K476) was used as the immunogen for the Zebrafish Mmp13a antibody.
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亚型
- Ig Fraction
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应用备注
- Optimal dilution of the Zebrafish Mmp13a antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Mmp13a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))
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别名
- Mmp13a
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背景
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Matrix metalloproteinase 13a (Mmp13a) is a member of the matrix metalloproteinase (MMP) family, enzymes that degrade components of the extracellular matrix (ECM). In zebrafish (Danio rerio), Mmp13a plays a pivotal role in tissue remodeling, skeletal development, and regeneration by regulating collagen breakdown and ECM turnover.
Mmp13a is particularly important during craniofacial morphogenesis, bone formation, and fin regeneration, where precise ECM remodeling is essential for cell migration, differentiation, and structural reorganization. Its expression is tightly regulated by signaling pathways such as Wnt, FGF, and TGF-i², and it can be induced in response to injury or developmental cues.
Due to its functional conservation with mammalian MMP13, zebrafish Mmp13a serves as a valuable model for studying osteogenesis, fibrosis, wound healing, and ECM-related diseases, including arthritis and cancer metastasis. Its robust expression during regeneration also makes it a useful biomarker for studies of tissue repair and regenerative biology.
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UniProt
- F1QCX8
抗原
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