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MMP13 抗体 (AA 110-476)

The 兔 多克隆 anti-MMP13 antibody (ABIN7870102) specifically detects MMP13 in WB 和 IHC (p). The antibody is reactive with 斑马鱼 samples.
产品编号 ABIN7870102
发货至: 中国
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Quick Overview for MMP13 抗体 (AA 110-476) (ABIN7870102)

抗原

See all MMP13 抗体
MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

适用

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斑马鱼

宿主

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克隆类型

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多克隆

标记

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This MMP13 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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    AA 110-476

    原理

    Zebrafish Mmp13a Antibody / Interstitial collagenase

    纯化方法

    Antigen affinity chromatography

    免疫原

    E. coli-derived zebrafish Mmp13a recombinant protein (amino acids D110-K476) was used as the immunogen for the Zebrafish Mmp13a antibody.

    亚型

    Ig Fraction
  • 应用备注

    Optimal dilution of the Zebrafish Mmp13a antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    储存条件

    4 °C,-20 °C

    储存方法

    After reconstitution, the Zebrafish Mmp13a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
  • 抗原

    MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

    别名

    Mmp13a

    背景

    Matrix metalloproteinase 13a (Mmp13a) is a member of the matrix metalloproteinase (MMP) family, enzymes that degrade components of the extracellular matrix (ECM). In zebrafish (Danio rerio), Mmp13a plays a pivotal role in tissue remodeling, skeletal development, and regeneration by regulating collagen breakdown and ECM turnover.

    Mmp13a is particularly important during craniofacial morphogenesis, bone formation, and fin regeneration, where precise ECM remodeling is essential for cell migration, differentiation, and structural reorganization. Its expression is tightly regulated by signaling pathways such as Wnt, FGF, and TGF-i², and it can be induced in response to injury or developmental cues.

    Due to its functional conservation with mammalian MMP13, zebrafish Mmp13a serves as a valuable model for studying osteogenesis, fibrosis, wound healing, and ECM-related diseases, including arthritis and cancer metastasis. Its robust expression during regeneration also makes it a useful biomarker for studies of tissue repair and regenerative biology.

    UniProt

    F1QCX8
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