Neurogranin 抗体 (AA 11-54)
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Quick Overview for Neurogranin 抗体 (AA 11-54) (ABIN7870089)
抗原
See all Neurogranin (NRGN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 11-54
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原理
- NRGN Antibody / Neurogranin
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纯化方法
- Affinity purified
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免疫原
- An E. coli-derived human protein (amino acids K11-K54) was used as the immunogen for the NRGN antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the NRGN antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the NRGN antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Neurogranin (NRGN)
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别名
- NRGN
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背景
- Neurogranin is a calmodulin-binding protein expressed primarily in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.
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UniProt
- Q92686
抗原
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