Syncoilin 抗体 (AA 11-465)
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Quick Overview for Syncoilin 抗体 (AA 11-465) (ABIN7870085)
抗原
See all Syncoilin (Sync) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 11-465
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原理
- Syncoilin Antibody / Sync
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived mouse Syncoilin/Sync recombinant protein (Position: D11-Q465) was used as the immunogen for the Syncoilin antibody.
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亚型
- IgG
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anti-Syncoilin (Sync) (AA 129-158), (N-Term) antibody
Sync 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB28681 unconjugated
anti-Syncoilin (Sync) (AA 133-163), (N-Term) antibodySync 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Syncoilin (Sync) (AA 169-458) antibodySync 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Syncoilin (Sync) (AA 371-420) antibodySync 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Syncoilin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Syncoilin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Syncoilin (Sync)
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别名
- Syncoilin
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背景
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Syncoilin antibody detects Syncoilin, encoded by the SYNC gene on chromosome 1p34.1. Syncoilin antibody is widely used to study this intermediate filament protein that links the dystrophin-associated protein complex (DAPC) to the cytoskeleton. Syncoilin is a muscle-specific protein expressed in skeletal and cardiac muscle, where it stabilizes sarcolemmal structures and contributes to muscle integrity. By anchoring desmin intermediate filaments to the DAPC, Syncoilin provides structural support essential for force transmission and resistance to mechanical stress. Its discovery expanded understanding of how the cytoskeleton connects with membrane complexes in muscle biology.
Structurally, Syncoilin contains a central coiled-coil domain flanked by head and tail regions typical of intermediate filament proteins. This organization allows Syncoilin to form filamentous networks and link them to membrane-associated complexes. Syncoilin interacts with alpha-dystrobrevin, a component of the DAPC, and with Desmin, an intermediate filament protein in muscle. These interactions anchor the cytoskeleton to the sarcolemma, stabilizing muscle fibers during contraction and relaxation.
Functionally, Syncoilin contributes to muscle integrity and repair. It stabilizes the DAPC, facilitates force transmission, and supports the structural integrity of sarcomeres. Knockout mouse models show defects in muscle fiber organization, increased susceptibility to stress, and impaired regeneration. Syncoilin expression is upregulated during muscle injury and regeneration, suggesting a role in repair processes. Researchers use Syncoilin antibody to study cytoskeletal organization, muscle pathophysiology, and repair mechanisms.
Clinically, Syncoilin has been investigated in muscular dystrophies. Although mutations in SYNC are rare, misregulation of Syncoilin contributes to dystrophic phenotypes. Abnormal expression patterns are reported in Duchenne and Becker muscular dystrophies, linking Syncoilin to the pathogenesis of these conditions. Its presence at the neuromuscular junction also implicates it in synaptic stability. Syncoilin is a promising marker for muscle disease diagnostics and therapeutic monitoring.
Experimentally, Syncoilin antibody is used in western blotting to detect the ~64 kDa protein, in immunohistochemistry to visualize localization at the sarcolemma, and in immunofluorescence to assess cytoskeletal organization. Immunoprecipitation with Syncoilin antibody helps identify its binding partners, including DAPC components. NSJ Bioreagents supplies Syncoilin antibody as a robust reagent for research into cytoskeletal dynamics, muscular dystrophy, and muscle regeneration. -
UniProt
- Q9EPM5
抗原
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