ATF5 抗体 (AA 11-275)
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北京 101111
Quick Overview for ATF5 抗体 (AA 11-275) (ABIN7870072)
抗原
See all ATF5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 11-275
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原理
- ATF5 Antibody / Activating transcription factor 5
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human ATF5 recombinant protein (Position: L11-R275) was used as the immunogen for the ATF5 antibody.
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亚型
- IgG
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anti-Activating Transcription Factor 5 (ATF5) antibody
ATF5 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 5 (ATF5) (AA 101-200) antibodyATF5 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4G5 unconjugated
anti-Activating Transcription Factor 5 (ATF5) (N-Term) antibodyATF5 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 5 (ATF5) (C-Term) antibodyVerified ATF5 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Activating Transcription Factor 5 (ATF5) (AA 101-150) antibodyATF5 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 5 (ATF5) (N-Term) antibodyATF5 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 5 (ATF5) (AA 1-282) antibodyATF5 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 5 (ATF5) antibodyATF5 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 9D8 unconjugated Recombinant Antibody
anti-Activating Transcription Factor 5 (ATF5) antibodyATF5 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Activating Transcription Factor 5 (ATF5) (acLys29) antibodyATF5 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the ATF5 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the ATF5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- ATF5 (Activating Transcription Factor 5 (ATF5))
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别名
- ATF5
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背景
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ATF5 antibody detects Activating transcription factor 5, a stress-responsive transcriptional regulator that modulates cell survival, differentiation, and neural development. Encoded by the ATF5 gene on chromosome 19q13.33, this protein is part of the activating transcription factor/cAMP response element-binding (ATF/CREB) family. ATF5 plays key roles in adaptive stress response, neuronal maturation, and maintenance of cellular homeostasis under nutrient deprivation, hypoxia, or endoplasmic reticulum stress.
Structurally, ATF5 is a 282-amino-acid nuclear protein of approximately 33 kilodaltons containing a basic leucine zipper (bZIP) domain that mediates DNA binding and dimerization with other bZIP family members. Through its N-terminal transactivation domain, ATF5 regulates gene expression involved in apoptosis suppression, differentiation control, and autophagy induction. It is ubiquitously expressed but shows high abundance in neural tissues, liver, and testis, where it participates in differentiation and stress adaptation.
The ATF5 antibody is widely used in neuroscience, oncology, and stress physiology research to study transcriptional regulation and survival signaling. Western blot analysis detects a 33 kilodalton band corresponding to ATF5, while immunofluorescence reveals strong nuclear localization and induction under stress conditions. This antibody enables researchers to analyze transcriptional programs governing neurogenesis, stress adaptation, and tumor resistance.
Functionally, ATF5 promotes cell survival under stress by inducing anti-apoptotic genes such as BCL2 and HSPA5 while repressing pro-apoptotic transcriptional regulators. In neurons, ATF5 regulates differentiation of neural progenitors and glial cells, influencing brain development and repair. In cancer cells, ATF5 expression confers resistance to nutrient and hypoxia-induced apoptosis, contributing to tumor growth and therapy resistance. The ATF5 antibody provides a reliable reagent for monitoring ATF5 activity in normal and stress-related transcriptional responses. NSJ Bioreagents validates this antibody for its applications, ensuring sensitive and consistent performance for gene regulation and stress signaling studies. -
UniProt
- Q9Y2D1
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途径
- Myometrial Relaxation and Contraction
抗原
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