SLIRP 抗体 (AA 11-109)
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Quick Overview for SLIRP 抗体 (AA 11-109) (ABIN7870062)
抗原
See all SLIRP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 11-109
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原理
- SLIRP Antibody / SRA stem-loop interacting RNA-binding protein
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SLIRP recombinant protein (Position: A11-F109) was used as the immunogen for the SLIRP antibody.
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亚型
- IgG
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anti-SRA Stem-Loop Interacting RNA Binding Protein (SLIRP) (N-Term) antibody
SLIRP 适用: 人, Cow, 犬, 马, Pig, 兔, 绵羊 WB 宿主: 兔 Polyclonal unconjugated
anti-SRA Stem-Loop Interacting RNA Binding Protein (SLIRP) (AA 1-100) antibodySLIRP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SRA Stem-Loop Interacting RNA Binding Protein (SLIRP) (N-Term) antibodySLIRP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SLIRP antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SLIRP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SLIRP (SRA Stem-Loop Interacting RNA Binding Protein (SLIRP))
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别名
- SLIRP
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背景
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SLIRP antibody detects SRA stem-loop interacting RNA-binding protein, a mitochondrial RNA-binding protein that modulates gene expression, oxidative phosphorylation, and steroid receptor signaling. SLIRP stabilizes mitochondrial mRNAs and participates in post-transcriptional regulation of respiratory chain components. The SLIRP antibody is widely used in mitochondrial biology and molecular endocrinology to study RNA regulation, energy metabolism, and hormone receptor activity.
SLIRP is encoded by the SLIRP gene located on human chromosome 14q13.3. The protein is approximately 111 amino acids long and contains an RNA recognition motif responsible for binding SRA (steroid receptor RNA activator) and mitochondrial transcripts. SLIRP localizes primarily to the mitochondrial matrix but also associates with nuclear hormone receptors, linking energy metabolism with transcriptional regulation.
The SLIRP antibody detects a 12 kilodalton band by western blot and exhibits mitochondrial and nuclear staining under immunofluorescence. SLIRP forms complexes with LRPPRC, ensuring stabilization and translation of mitochondrial mRNAs encoding respiratory complex subunits. Loss of SLIRP leads to reduced mitochondrial translation, impaired oxidative phosphorylation, and decreased ATP production.
Beyond mitochondrial function, SLIRP interacts with steroid receptors such as estrogen receptor alpha and glucocorticoid receptor, modulating their transcriptional activity. By coupling nuclear hormone signaling with mitochondrial bioenergetics, SLIRP coordinates cellular responses to hormonal and metabolic cues. Dysregulation of SLIRP expression contributes to metabolic disorders, neurodegeneration, and certain cancers where mitochondrial dysfunction plays a role.
Because SLIRP integrates transcriptional control and mitochondrial energy metabolism, it represents a valuable target for understanding gene expression coordination and metabolic adaptation. NSJ Bioreagents provides a validated SLIRP antibody optimized for western blot, immunofluorescence, and mitochondrial studies, supporting investigations into RNA processing, hormone receptor function, and oxidative metabolism. -
UniProt
- Q9GZT3
抗原
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