STK16 抗体 (AA 109-268)
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Quick Overview for STK16 抗体 (AA 109-268) (ABIN7870054)
抗原
See all STK16 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 109-268
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原理
- STK16 Antibody / Serine/threonine-protein kinase 16
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human STK16 recombinant protein (Position: E109-L268) was used as the immunogen for the STK16 antibody.
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亚型
- IgG
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anti-serine/threonine Kinase 16 (STK16) (AA 1-305) antibody
STK16 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal M2 unconjugated
anti-serine/threonine Kinase 16 (STK16) antibodySTK16 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 16 (STK16) (AA 1-305) antibodySTK16 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 16 (STK16) (AA 1-306) antibodySTK16 适用: 人 WB, ELISA, IHC, IHC (p), RNAi 宿主: 小鼠 Monoclonal M2 unconjugated
anti-serine/threonine Kinase 16 (STK16) (AA 1-305) antibodySTK16 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 16 (STK16) (AA 1-100) antibodySTK16 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G6 unconjugated
anti-serine/threonine Kinase 16 (STK16) (AA 257-286), (C-Term) antibodySTK16 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB3532 unconjugated
anti-serine/threonine Kinase 16 (STK16) (Middle Region) antibodySTK16 适用: 人, 小鼠, 大鼠, 犬, 山羊, 兔, Cow, 豚鼠, 马, Pig, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 16 (STK16) (AA 257-286), (C-Term) antibodySTK16 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 16 (STK16) (AA 1-305) antibodySTK16 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the STK16 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the STK16 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- STK16 (serine/threonine Kinase 16 (STK16))
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别名
- STK16
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背景
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STK16 antibody detects Serine/threonine-protein kinase 16, a membrane-associated kinase that regulates secretion, Golgi organization, and intracellular trafficking. The UniProt recommended name is Serine/threonine-protein kinase 16 (STK16). This constitutively active kinase associates with the Golgi apparatus and modulates vesicular transport between the Golgi and plasma membrane.
Functionally, STK16 antibody identifies a 305-amino-acid protein with a typical serine/threonine kinase domain and a C-terminal myristoylation site that anchors it to membranes. STK16 phosphorylates various substrates involved in exocytosis, including components of the SNARE complex. It is essential for maintaining Golgi structure, regulating secretion, and coordinating protein sorting within the secretory pathway.
The STK16 gene is located on chromosome 2q31.1 and is ubiquitously expressed, with enrichment in liver, pancreas, and secretory epithelial tissues. STK16i 1/2s kinase activity is regulated by autophosphorylation and membrane association. It also participates in cell cycle progression and polarized transport, suggesting broader roles in organelle biogenesis and signal transduction.
Pathologically, aberrant STK16 function has been implicated in tumorigenesis, metabolic disease, and Golgi stress. Overexpression may enhance secretion and proliferation, while inhibition disrupts vesicular trafficking and protein glycosylation. Research using STK16 antibody contributes to understanding kinase-mediated control of membrane traffic and its implications in disease and cellular physiology.
STK16 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to visualize Golgi-associated kinases and phosphorylation-dependent trafficking. NSJ Bioreagents offers STK16 antibody reagents optimized for studies of secretion, Golgi function, and signal transduction.
Structurally, STK16 belongs to the NAK (Numb-associated kinase) family and features an N-lobe typical of protein kinases, with regulatory elements that stabilize its constitutive activity. This antibody supports detailed characterization of STK16's role in kinase signaling and Golgi organization. -
UniProt
- O75716
抗原
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