EDC4 抗体 (AA 1082-1388)
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Quick Overview for EDC4 抗体 (AA 1082-1388) (ABIN7870039)
抗原
See all EDC4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1082-1388
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原理
- EDC4 Antibody / Enhancer of mRNA-decapping protein 4
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纯化方法
- Affinity purified
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免疫原
- An E. coli-derived human protein (amino acids K1082-L1388) was used as the immunogen for the EDC4 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the EDC4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the EDC4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- EDC4 (Enhancer of mRNA Decapping 4 (EDC4))
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别名
- EDC4
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背景
- Enhancer of mRNA-decapping protein 4 is a protein that in humans is encoded by the EDC4 gene. Enhancer of mRNA decapping 4 (EDC4) was originally identified as the autoantigen Ge-1 from a Sjogren's syndrome patient later diagnosed with primary biliary cirrhosis. EDC4 (also known as HEDLS) was later identified as an essential component of cytoplasmic P-bodies responsible for mRNA decapping and degradation. Identified EDC4 protein is found as a pair of isoforms generated by alternative splicing and contains several WD domains and a putative nuclear localization signal. EDC4 co-localizes with other P-body decapping proteins such as DCP1A, DCP2 and GW182. Experimental evidence suggests that EDC4 may be involved in miRNA-mediated translation repression.
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UniProt
- Q6P2E9
抗原
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