SSH3 抗体 (AA 108-620)
Our Local Distributor
北京 101111
Quick Overview for SSH3 抗体 (AA 108-620) (ABIN7870034)
抗原
See all SSH3 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 108-620
-
原理
- SSH3 Antibody / Slingshot homolog 3
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived human SSH3 recombinant protein (Position: Q108-Q620) was used as the immunogen for the SSH3 antibody.
-
亚型
- IgG
-
-
anti-Slingshot Homolog 3 (SSH3) (AA 293-391) antibody
SSH3 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 6F9 unconjugated
anti-Slingshot Homolog 3 (SSH3) (AA 575-602), (C-Term) antibodySSH3 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB19876 unconjugated
anti-Slingshot Homolog 3 (SSH3) (AA 1-659) antibodySSH3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Slingshot Homolog 3 (SSH3) (Internal Region) antibodySSH3 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Slingshot Homolog 3 (SSH3) (AA 480-659) antibodySSH3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Slingshot Homolog 3 (SSH3) (AA 582-610), (C-Term) antibodySSH3 适用: 人 WB, IF, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Slingshot Homolog 3 (SSH3) (AA 10-43), (Ser37) antibodySSH3 适用: 人 WB 宿主: 兔 Polyclonal RB56878 unconjugated
anti-Slingshot Homolog 3 (SSH3) antibodySSH3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Slingshot Homolog 3 (SSH3) (AA 10-43), (pSer37) antibodySSH3 适用: 人 WB 宿主: 兔 Polyclonal RB56878 unconjugated
anti-Slingshot Homolog 3 (SSH3) (AA 293-391) antibodySSH3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the SSH3 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the SSH3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- SSH3 (Slingshot Homolog 3 (SSH3))
-
别名
- SSH3
-
背景
-
SSH3 antibody detects Slingshot homolog 3, a member of the slingshot family of serine/threonine phosphatases that regulate actin filament dynamics through dephosphorylation of cofilin. The UniProt recommended name is Slingshot homolog 3 (SSH3). This phosphatase modulates cytoskeletal reorganization, cell migration, and synaptic remodeling by maintaining the balance between phosphorylated and active cofilin.
Functionally, SSH3 antibody identifies a 575-amino-acid cytoplasmic enzyme that acts downstream of Rho family GTPases. SSH3 dephosphorylates cofilin at serine 3, restoring its actin-severing activity and promoting filament turnover. The protein also interacts with scaffolding components such as 14-3-3 proteins and LIM kinases, coordinating actin remodeling in response to extracellular cues.
The SSH3 gene is located on chromosome 3p21.31 and is widely expressed in brain, muscle, and epithelial tissues. SSH3 contributes to cell shape changes, migration, and polarity through dynamic actin regulation. In neurons, it participates in synaptic plasticity and axon guidance by fine-tuning cytoskeletal rearrangements during development and signaling.
Pathologically, aberrant SSH3 activity disrupts cytoskeletal organization and has been associated with cancer metastasis and neurological disorders. Overactivation enhances cell motility and invasion, whereas loss of function impairs normal morphogenesis. Research with SSH3 antibody supports studies on actin regulation, neuronal development, and signal transduction.
SSH3 antibody is suitable for western blotting, immunofluorescence, and immunohistochemistry, enabling precise detection of SSH3 in various cell types. NSJ Bioreagents provides SSH3 antibody reagents validated for actin cytoskeleton and phosphatase signaling research.
Structurally, SSH3 contains an N-terminal catalytic domain related to the dual-specificity phosphatase family and C-terminal regions mediating protein-protein interactions. Its localization and activity are regulated by phosphorylation and 14-3-3 binding. This antibody facilitates analysis of SSH3's role in actin filament turnover and cell motility control. -
UniProt
- Q8TE77
抗原
-
