PLBD2 抗体 (AA 108-525)
Our Local Distributor
北京 101111
Quick Overview for PLBD2 抗体 (AA 108-525) (ABIN7870033)
抗原
See all PLBD2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 108-525
-
原理
- PLBD2 Antibody / Phospholipase B domain-containing protein 2
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived human PLBD2 recombinant protein (Position: Q108-Q525) was used as the immunogen for the PLBD2 antibody.
-
亚型
- IgG
-
-
anti-Phospholipase B Domain Containing 2 (PLBD2) antibody
PLBD2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Phospholipase B Domain Containing 2 (PLBD2) (AA 36-585) antibodyPLBD2 适用: 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase B Domain Containing 2 (PLBD2) (AA 47-594) antibodyPLBD2 适用: 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase B Domain Containing 2 (PLBD2) antibody (Biotin)PLBD2 适用: 小鼠 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal Biotin
anti-Phospholipase B Domain Containing 2 (PLBD2) antibody (FITC)PLBD2 适用: 小鼠 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal FITC
anti-Phospholipase B Domain Containing 2 (PLBD2) antibody (HRP)PLBD2 适用: 小鼠 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal HRP
anti-Phospholipase B Domain Containing 2 (PLBD2) antibodyPLBD2 适用: 小鼠 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the PLBD2 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the PLBD2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- PLBD2 (Phospholipase B Domain Containing 2 (PLBD2))
-
别名
- PLBD2
-
背景
-
PLBD2 antibody detects Phospholipase B domain-containing protein 2, a lysosomal enzyme implicated in lipid metabolism and cellular membrane remodeling. The UniProt recommended name is Phospholipase B domain-containing protein 2 (PLBD2). This protein belongs to the phospholipase B-like superfamily, which hydrolyzes both acyl chains of phospholipids to generate free fatty acids and glycerophosphates. Although the enzymatic activity of PLBD2 is still under characterization, evidence suggests roles in lipid turnover, immune defense, and autophagy.
Functionally, PLBD2 antibody recognizes a 516-amino-acid protein localized primarily in lysosomes and the endoplasmic reticulum. PLBD2 contains a conserved phospholipase B-like catalytic domain, which may mediate hydrolysis of membrane phospholipids and lysophospholipids. By modulating lipid composition, PLBD2 contributes to vesicle formation, endosomal trafficking, and lipid droplet metabolism. Its expression is induced by inflammatory cytokines and lipid stress, indicating a regulatory role in lipid homeostasis and immune signaling.
The PLBD2 gene is located on chromosome 12q13.13 and encodes a protein that shares structural features with classical phospholipases but displays distinct substrate specificity. While its catalytic mechanism remains partially defined, studies suggest that PLBD2 may participate in lipid recycling and detoxification under stress conditions. Proteomic analyses have identified PLBD2 as part of the lysosomal proteome, implicating it in membrane degradation and recycling of lipid components.
In immunology, PLBD2 has been linked to macrophage activation and inflammatory signaling. It may function as a lipid-modifying enzyme that influences phagosome maturation and pathogen clearance. Dysregulation of PLBD2 expression has been observed in metabolic disorders and cancers, suggesting that it plays a broader role in cellular metabolism and immune modulation. Elevated PLBD2 levels correlate with altered phospholipid profiles and increased autophagic activity in response to nutrient deprivation.
PLBD2 antibody is employed in lipidomics, immunology, and cell biology studies to investigate lysosomal function and lipid signaling pathways. It is useful for immunoblotting, immunofluorescence, and proteomic profiling of organelle-specific proteins. The enzyme's localization in the lysosomal compartment makes it an important marker for studies of membrane dynamics and lipid degradation. NSJ Bioreagents provides PLBD2 antibody reagents validated for use in research on lipid metabolism, autophagy, and membrane trafficking.
Structurally, PLBD2 contains the conserved GXGXXG motif characteristic of lipid-hydrolyzing enzymes and a putative signal peptide for targeting to intracellular membranes. Its domain organization suggests roles in lipid recognition and hydrolysis. Post-translational regulation may involve glycosylation and proteolytic processing that modulate catalytic efficiency. Ongoing research continues to clarify its enzymatic specificity and physiological relevance in lipid remodeling. -
UniProt
- Q8NHP8
抗原
-
