GHDC 抗体 (AA 108-426)
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Quick Overview for GHDC 抗体 (AA 108-426) (ABIN7870031)
抗原
See all GHDC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 108-426
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原理
- GHDC Antibody / GH3 domain-containing protein
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human GHDC recombinant protein (Position: E108-S426) was used as the immunogen for the GHDC antibody.
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亚型
- IgG
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anti-GH3 Domain Containing (GHDC) (AA 1-530) antibody
GHDC 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-GH3 Domain Containing (GHDC) (N-Term) antibodyGHDC 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GH3 Domain Containing (GHDC) (AA 70-119) antibodyGHDC 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-GH3 Domain Containing (GHDC) (AA 108-426) antibodyGHDC 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-GH3 Domain Containing (GHDC) (N-Term) antibodyGHDC 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GHDC antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GHDC antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GHDC (GH3 Domain Containing (GHDC))
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别名
- GHDC
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背景
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GHDC antibody detects GH3 domain-containing protein, encoded by the GHDC gene on chromosome 5q31.3. GHDC antibody is used in studies of protein-protein interactions, signaling pathways, and developmental biology. GHDC is a relatively uncharacterized protein thought to play roles in cellular signaling and scaffolding functions through its GH3 domain, which mediates interactions with other signaling proteins. Expression is observed in multiple tissues, including brain, liver, kidney, and immune cells, suggesting broad biological roles.
Structurally, GHDC contains a conserved GH3 domain, originally identified in proteins involved in signaling and cytoskeletal organization. The GH3 domain enables GHDC to act as an adaptor protein, linking signaling molecules within cellular pathways. The protein also contains coiled-coil motifs that may support oligomerization or interactions with structural proteins. These features position GHDC as a potential mediator of cytoskeletal and signaling regulation.
Functionally, GHDC is predicted to participate in cytoskeletal organization, vesicle trafficking, and intracellular signaling. While detailed functions are still under investigation, experimental data suggest GHDC influences processes such as cell migration, adhesion, and signal transduction. Knockdown or mutation may disrupt these pathways, although phenotypic outcomes are not yet well defined. Researchers apply GHDC antibody to explore the roles of novel domain-containing proteins and their integration into known signaling networks.
Clinically, GHDC remains underexplored, but variants have been identified in genetic screens of developmental disorders and neurological disease. Genome-wide association studies have linked GHDC locus variants to neuropsychiatric traits, though causality remains to be determined. Altered expression of GHDC has been observed in some cancers, hinting at roles in proliferation or migration. Ongoing research aims to define its contributions to disease. NSJ Bioreagents supplies GHDC antibody to support early-stage research on this uncharacterized protein.
Experimentally, GHDC antibody is used in western blotting to detect the ~90 kDa protein, in immunofluorescence microscopy to study localization, and in immunohistochemistry to assess tissue expression. Immunoprecipitation with GHDC antibody allows identification of potential binding partners and domain-mediated interactions. -
UniProt
- Q8N2G8
抗原
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