SMC1B 抗体 (AA 106-1221)
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北京 101111
Quick Overview for SMC1B 抗体 (AA 106-1221) (ABIN7869992)
抗原
See all SMC1B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 106-1221
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原理
- SMC1B Antibody / Structural maintenance of chromosomes protein 1B
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SMC1B recombinant protein (Position: R106-D1221) was used as the immunogen for the SMC1B antibody.
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亚型
- IgG
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anti-Structural Maintenance of Chromosomes 1B (SMC1B) (N-Term) antibody
SMC1B 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 1B (SMC1B) (AA 551-660) antibodySMC1B 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6A10 unconjugated
anti-Structural Maintenance of Chromosomes 1B (SMC1B) (AA 954-1060) antibodySMC1B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 1B (SMC1B) (AA 737-765) antibodySMC1B 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB33824 unconjugated
anti-Structural Maintenance of Chromosomes 1B (SMC1B) (pSer957) antibodySMC1B 适用: 人 WB, ELISA, IHC, FM 宿主: 小鼠 Monoclonal 5D11-G5 unconjugated
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应用备注
- Optimal dilution of the SMC1B antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SMC1B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SMC1B (Structural Maintenance of Chromosomes 1B (SMC1B))
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别名
- SMC1B
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背景
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SMC1B antibody detects Structural maintenance of chromosomes protein 1B, a cohesin complex component essential for chromosome cohesion during meiosis. Encoded by the SMC1B gene on chromosome 22q13.33, this protein is a meiosis-specific paralog of the somatic cohesin subunit SMC1A. SMC1B forms part of the cohesin ring complex that links sister chromatids and facilitates homologous recombination and synapsis. It ensures accurate chromosome segregation and genomic integrity in germ cells, playing a critical role in gametogenesis and fertility.
SMC1B forms heterodimers with SMC3 and associates with meiosis-specific cohesin components such as REC8, STAG3, and RAD21L. Together, these proteins establish and maintain cohesion between homologous chromosomes from prophase I until anaphase I, preventing premature separation. SMC1B also contributes to chromatin organization, double-strand break repair, and gene regulation during meiosis. Its expression is restricted mainly to germ cells in the testes and ovaries, though low levels may be detected in certain somatic tissues under specific developmental conditions.
The SMC1B antibody is used in cell biology, reproductive, and chromatin research to investigate cohesin complex formation and meiotic chromosome dynamics. Western blot analysis identifies a 145 kilodalton band corresponding to SMC1B, while immunofluorescence reveals chromosomal axis localization in meiotic cells. This antibody supports studies of meiotic cohesion, synaptonemal complex assembly, and chromosomal recombination.
Deficiency or mutation of SMC1B disrupts chromosome pairing and leads to infertility, meiotic arrest, or aneuploidy. Beyond meiosis, SMC1B may contribute to chromatin architecture and DNA repair in somatic cells. The SMC1B antibody provides a powerful tool for characterizing cohesin-mediated chromosome interactions and meiotic mechanisms. NSJ Bioreagents supplies this antibody validated for western blotting and immunofluorescence, ensuring reliable performance in chromosomal cohesion and germ cell research. -
UniProt
- Q8NDV3
抗原
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