CTR9 抗体 (AA 1022-1056)
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北京 101111
Quick Overview for CTR9 抗体 (AA 1022-1056) (ABIN7869922)
抗原
See all CTR9 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1022-1056
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原理
- Ctr9 Antibody
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 1022-1056 from the mouse protein was used as the immunogen for the Ctr9 antibody.
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亚型
- Ig Fraction
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anti-RNA Polymerase-Associated Protein CTR9 Homolog (CTR9) (AA 1022-1056), (C-Term) antibody
CTR9 适用: 人, 小鼠 WB, IHC (p), IF 宿主: 兔 Polyclonal RB51042 unconjugated
anti-RNA Polymerase-Associated Protein CTR9 Homolog (CTR9) (AA 751-850) antibodyCTR9 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-RNA Polymerase-Associated Protein CTR9 Homolog (CTR9) (AA 1123-1173) antibodyCTR9 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-RNA Polymerase-Associated Protein CTR9 Homolog (CTR9) (AA 1123-1173) antibodyCTR9 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
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应用备注
- The stated application concentrations are suggested starting points. Titration of the Ctr9 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Ctr9 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- CTR9 (RNA Polymerase-Associated Protein CTR9 Homolog (CTR9))
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别名
- Ctr9
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背景
- RNA polymerase-associated protein CTR9 homolog is a component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys- 4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys- 4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription (By similarity). Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency, this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway, may regulate DNA-association of STAT3.
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UniProt
- Q62018
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途径
- Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance
抗原
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