MAP1B 抗体 (AA 102-1849)
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Quick Overview for MAP1B 抗体 (AA 102-1849) (ABIN7869909)
抗原
See all MAP1B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 102-1849
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原理
- MAP1B Antibody / Microtubule-associated protein 1B
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human MAP1B recombinant protein (Position: H102-R1849) was used as the immunogen for the MAP1B antibody.
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亚型
- IgG
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anti-Microtubule-Associated Protein 1B (MAP1B) (AA 2203-2464) antibody
MAP1B 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 1B (MAP1B) (AA 2207-2468) antibodyMAP1B 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 1B (MAP1B) (Internal Region) antibodyMAP1B 适用: 人, 小鼠, 大鼠 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 1B (MAP1B) (AA 451-550) antibodyMAP1B 适用: 人, 小鼠, 大鼠 ELISA, FACS, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 1B (MAP1B) (AA 451-550) antibody (FITC)MAP1B 适用: 人, 小鼠, 大鼠 FACS, IF (cc), IF (p) 宿主: 兔 Polyclonal FITC
anti-Microtubule-Associated Protein 1B (MAP1B) antibodyMAP1B 适用: 人, 大鼠, Cow IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
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应用备注
- Optimal dilution of the MAP1B antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MAP1B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MAP1B (Microtubule-Associated Protein 1B (MAP1B))
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别名
- MAP1B
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背景
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MAP1B antibody detects Microtubule-associated protein 1B, a neuronal cytoskeletal protein that regulates microtubule stability, axon guidance, and neuronal differentiation. The UniProt recommended name is Microtubule-associated protein 1B (MAP1B). This large microtubule-binding protein plays an essential role during nervous system development by stabilizing and organizing microtubule networks within axons and dendrites.
Functionally, MAP1B antibody identifies a precursor protein of approximately 2,460 amino acids that is proteolytically cleaved into heavy and light chains. These subunits assemble with microtubules and actin filaments, promoting cytoskeletal crosslinking. MAP1B is enriched in developing neurons, where it modulates growth cone dynamics and neurite outgrowth, influencing axonal pathfinding and regeneration.
The MAP1B gene is located on chromosome 5q13.2 and is highly expressed in the central and peripheral nervous systems. MAP1B associates with other neuronal cytoskeletal proteins, such as tau and MAP2, to regulate polymerization and microtubule stability. Phosphorylation of MAP1B by kinases including GSK3 and CDK5 modulates its binding affinity and spatial localization, fine-tuning neuronal polarity and maturation.
Pathologically, aberrant MAP1B expression or phosphorylation is associated with neurodevelopmental and neurodegenerative diseases, including Alzheimeri 1/2s and Parkinsoni 1/2s disease. In tumor cells, MAP1B re-expression correlates with altered cytoskeletal organization and invasiveness. Research using MAP1B antibody supports studies in axonal transport, cytoskeletal remodeling, and neuronal repair mechanisms.
MAP1B antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect neuronal microtubule-associated proteins. NSJ Bioreagents offers MAP1B antibody reagents optimized for neurobiology, cytoskeletal, and developmental research applications.
Structurally, Microtubule-associated protein 1B contains multiple microtubule-binding domains and an actin-binding region, facilitating cytoskeletal integration. Its dynamic phosphorylation pattern determines its localization and activity during neuron growth and regeneration. This antibody provides a reliable tool to examine MAP1B's regulatory functions in cytoskeletal organization and axonal development. -
UniProt
- P46821
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途径
- Microtubule Dynamics, Regulation of Cell Size
抗原
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