Recombinant CSTA 抗体 (AA 1-98)
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Quick Overview for Recombinant CSTA 抗体 (AA 1-98) (ABIN7869663)
抗原
See all CSTA 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-98
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原理
- Recombinant Cystatin A Antibody / CSTA
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant fragment of human CSTA protein (within amino acids 1-98) was used as the immunogen for the recombinant Cystatin A antibody.
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亚型
- IgG, kappa
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anti-Cystatin A (Stefin A) (CSTA) antibody
CSTA 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal CPTC-CSTA-1 unconjugated
anti-Cystatin A (Stefin A) (CSTA) (AA 2-98) antibodyCSTA 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Cystatin A (Stefin A) (CSTA) (AA 1-98) antibodyCSTA 适用: 人 IHC 宿主: 小鼠 Monoclonal CSTA-2882 unconjugated
anti-Cystatin A (Stefin A) (CSTA) (C-Term) antibodyCSTA 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Cystatin A (Stefin A) (CSTA) (full length) antibodyCSTA 适用: 人 IHC 宿主: 小鼠 Monoclonal 461M unconjugated
anti-Cystatin A (Stefin A) (CSTA) (AA 1-98) antibodyCSTA 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cystatin A (Stefin A) (CSTA) (C-Term) antibodyCSTA 适用: 人, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cystatin A (Stefin A) (CSTA) (AA 1-98) antibodyCSTA 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Cystatin A (Stefin A) (CSTA) antibodyCSTA 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB5665 unconjugated Recombinant Antibody
anti-Cystatin A (Stefin A) (CSTA) (AA 1-98) antibodyCSTA 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1A11 unconjugated
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应用备注
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1.Optimal dilution of the recombinant Cystatin A antibody should be determined by the researcher.
2. This recombinant Cystatin A antibody was recombinantly expressed in CHO cells. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant Cystatin A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- CSTA (Cystatin A (Stefin A) (CSTA))
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别名
- Cystatin A
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背景
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Cystatin A antibody targets Cystatin A, a cytoplasmic cysteine protease inhibitor encoded by the CSTA gene and a member of the type I cystatin family. Cystatin A is also widely known as Stefin A and functions as an endogenous inhibitor of papain-like cysteine proteases, including cathepsins B, H, and L. By regulating intracellular protease activity, Cystatin A plays an essential role in protecting epithelial cells from excessive proteolysis and maintaining tissue integrity.
Cystatin A is predominantly localized in the cytoplasm and is highly expressed in stratified squamous epithelia such as epidermis, oral mucosa, esophagus, and cervix. It is closely associated with epithelial differentiation and keratinization processes, where controlled protease inhibition is required for proper barrier formation. Cystatin A antibody detection is therefore useful for studying epithelial maturation, protease balance, and barrier-related biology.
Functionally, Cystatin A binds tightly to cysteine proteases and suppresses their enzymatic activity, thereby influencing cellular processes including apoptosis, inflammation, and cell migration. Through modulation of cathepsin activity, Cystatin A contributes to controlled protein turnover and cellular homeostasis. CSTA antibody reagents support research into protease-inhibitor networks that are critical for normal epithelial function and stress responses.
Altered expression of Cystatin A has been reported in multiple disease contexts, particularly in epithelial-derived cancers. Reduced or heterogeneous CSTA expression has been associated with increased invasiveness and poor differentiation, while strong expression is often retained in well-differentiated squamous cell carcinomas. Changes in Cystatin A levels have also been linked to inflammatory skin disorders and barrier dysfunction, highlighting its relevance in both cancer biology and dermatological research.
Clone CSTA/9087R is designed to recognize Cystatin A in research applications. Cystatin A antibody reagents are suitable for detecting protein expression and localization in epithelial tissues and tumor samples, supporting investigations into protease regulation, epithelial differentiation, and disease-associated alterations in cysteine protease inhibition. -
UniProt
- P01040
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途径
- Response to Water Deprivation
抗原
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