TGM4 抗体 (AA 1-684)
Our Local Distributor
北京 101111
Quick Overview for TGM4 抗体 (AA 1-684) (ABIN7869525)
抗原
See all TGM4 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-684
-
原理
- TGM4 Antibody / Transglutaminase 4
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived human TGM4 recombinant protein (Position: M1-K684) was used as the immunogen for the TGM4 antibody.
-
亚型
- IgG
-
-
anti-Transglutaminase 4 (Prostate) (TGM4) (N-Term) antibody
TGM4 适用: 人, 小鼠, 大鼠, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transglutaminase 4 (Prostate) (TGM4) (AA 1-684) antibodyTGM4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Transglutaminase 4 (Prostate) (TGM4) antibodyTGM4 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transglutaminase 4 (Prostate) (TGM4) (AA 135-164) antibodyTGM4 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21271 unconjugated
anti-Transglutaminase 4 (Prostate) (TGM4) (AA 1-684) antibodyTGM4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transglutaminase 4 (Prostate) (TGM4) (C-Term) antibodyTGM4 适用: 人 ELISA, WB, IHC, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Transglutaminase 4 (Prostate) (TGM4) (AA 361-410) antibodyTGM4 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transglutaminase 4 (Prostate) (TGM4) (AA 49-63) antibodyVerified TGM4 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-Transglutaminase 4 (Prostate) (TGM4) (Middle Region) antibodyTGM4 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the TGM4 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the TGM4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- TGM4 (Transglutaminase 4 (Prostate) (TGM4))
-
别名
- TGM4
-
背景
-
TGM4 antibody detects Transglutaminase 4, an enzyme that catalyzes the cross-linking of proteins through ?-(gamma-glutamyl) lysine bonds, contributing to the stabilization of extracellular structures. The UniProt recommended name is Transglutaminase 4 (TGM4). This enzyme is part of the transglutaminase family, which mediates post-translational protein modification and plays critical roles in cell adhesion, differentiation, and reproductive physiology.
Functionally, TGM4 antibody identifies a 684-amino-acid secreted and membrane-associated protein primarily expressed in the prostate and other reproductive tissues. TGM4 cross-links seminal plasma proteins, forming insoluble networks that contribute to semen coagulation and fertility. It may also participate in epithelial barrier formation and immune defense in the urogenital tract.
The TGM4 gene is located on chromosome 3p21.33 and is expressed in male reproductive tissues and epithelial surfaces. TGM4 activity is regulated by calcium ions and thiol-reactive compounds, influencing enzyme conformation and catalytic activity.
Pathologically, altered TGM4 expression has been associated with prostate cancer and infertility. Decreased expression correlates with impaired seminal coagulation, while increased levels are observed in prostate tumors and serve as potential diagnostic biomarkers. Research using TGM4 antibody supports studies in enzymology, reproductive biology, and oncology.
TGM4 antibody is validated for western blotting, immunohistochemistry, and ELISA to detect transglutaminase enzymes. NSJ Bioreagents provides TGM4 antibody reagents optimized for reproductive biology, enzymatic modification, and cancer biomarker studies.
Structurally, Transglutaminase 4 consists of a catalytic core domain containing the active site cysteine, histidine, and aspartate residues, flanked by beta-sandwich and C-terminal domains that mediate substrate binding. This antibody enables analysis of TGM4's role in cross-linking reactions and reproductive function. -
UniProt
- P49221
抗原
-
