NUP93 抗体 (AA 1-677)
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Quick Overview for NUP93 抗体 (AA 1-677) (ABIN7869524)
抗原
See all NUP93 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-677
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原理
- NUP93 Antibody / Nuclear pore complex protein Nup93
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human NUP93 recombinant protein (Position: M1-Q677) was used as the immunogen for the NUP93 antibody.
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亚型
- IgG
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anti-Nucleoporin 93kDa (NUP93) (AA 20-54) antibody
NUP93 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB54886 unconjugated
anti-Nucleoporin 93kDa (NUP93) (AA 752-782) antibodyNUP93 适用: 人 WB 宿主: 兔 Polyclonal RB54978 unconjugated
anti-Nucleoporin 93kDa (NUP93) antibodyNUP93 适用: 人 DB 宿主: 小鼠 Monoclonal 3332C2a unconjugated
anti-Nucleoporin 93kDa (NUP93) (AA 14-180) antibodyNUP93 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nucleoporin 93kDa (NUP93) (AA 670-819) antibodyNUP93 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Nucleoporin 93kDa (NUP93) (AA 606-656) antibodyNUP93 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Nucleoporin 93kDa (NUP93) antibodyNUP93 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the NUP93 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the NUP93 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- NUP93 (Nucleoporin 93kDa (NUP93))
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别名
- NUP93
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背景
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NUP93 antibody detects Nuclear pore complex protein Nup93, encoded by the NUP93 gene on chromosome 16p13.11. NUP93 antibody is widely used to study nucleocytoplasmic transport, nuclear pore structure, and gene regulation. NUP93 is a core scaffold nucleoporin essential for assembly and function of the nuclear pore complex (NPC). It contributes to selective transport of macromolecules between the nucleus and cytoplasm, maintaining nuclear integrity and regulating gene expression. NUP93 expression is ubiquitous, consistent with its fundamental role in cell viability.
Structurally, NUP93 is a ~93 kDa protein with coiled-coil domains that mediate interactions with other nucleoporins. It forms part of the inner ring of the NPC, interacting with NUP205, NUP188, and NUP62. These associations stabilize the pore scaffold and provide docking sites for transport factors. Mutations in NUP93 disrupt NPC assembly, impairing nuclear transport and transcriptional regulation.
Functionally, NUP93 regulates nuclear transport by forming the selective barrier that allows import of nuclear proteins and export of RNA. It also participates in mitosis, where disassembly and reassembly of nuclear pores are tightly controlled. NUP93 influences chromatin organization and transcription by anchoring regulatory proteins at the nuclear periphery. Knockdown of NUP93 leads to nuclear transport defects, growth arrest, and apoptosis. Researchers use NUP93 antibody to explore nuclear transport, chromatin regulation, and nuclear architecture.
Clinically, NUP93 mutations are linked to steroid-resistant nephrotic syndrome, a kidney disorder characterized by proteinuria and renal failure. Deficiency disrupts nuclear pore assembly in podocytes, impairing kidney function. NUP93 has also been associated with developmental abnormalities and cancer, where altered nuclear transport contributes to oncogenesis. NSJ Bioreagents provides NUP93 antibody as a reagent for nuclear transport and disease-related studies.
Experimentally, NUP93 antibody is applied in western blotting to detect the ~93 kDa protein, in immunofluorescence microscopy to visualize nuclear pores, and in immunohistochemistry to assess tissue distribution. Immunoprecipitation with NUP93 antibody isolates nuclear pore complexes, supporting biochemical studies of transport machinery. -
UniProt
- Q8N1F7
抗原
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