MCM9 抗体 (AA 1-644)
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Quick Overview for MCM9 抗体 (AA 1-644) (ABIN7869515)
抗原
See all MCM9 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-644
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原理
- MCM9 Antibody / Minichromosome maintenance complex component 9
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human MCM9 recombinant protein (Position: M1-L644) was used as the immunogen for the MCM9 antibody.
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亚型
- IgG
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anti-Minichromosome Maintenance Deficient 9 (MCM9) (AA 1-391) antibody
MCM9 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 9 (MCM9) (C-Term) antibodyMCM9 适用: 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 9 (MCM9) (N-Term) antibodyMCM9 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 9 (MCM9) (N-Term) antibodyMCM9 适用: 人, 小鼠, Cow, 犬, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 9 (MCM9) (AA 316-345), (C-Term) antibodyMCM9 适用: 人 WB 宿主: 兔 Polyclonal RB32018 unconjugated
anti-Minichromosome Maintenance Deficient 9 (MCM9) (N-Term) antibodyMCM9 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 9 (MCM9) (AA 316-345) antibodyMCM9 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the MCM9 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MCM9 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MCM9 (Minichromosome Maintenance Deficient 9 (MCM9))
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别名
- MCM9
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背景
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MCM9 antibody detects Minichromosome maintenance complex component 9, a helicase-associated protein essential for DNA replication licensing and homologous recombination repair. Encoded by the MCM9 gene on chromosome 6q22.31, this nuclear protein functions as part of the MCM8-MCM9 complex, which assists in DNA replication origin activation and double-strand break repair. MCM9 plays a critical role in maintaining genomic stability and facilitating proper DNA synthesis during S phase.
Structurally, MCM9 is a 1,143-amino-acid nuclear protein of approximately 130 kilodaltons containing an AAA+ ATPase domain typical of MCM family helicases. Although it lacks intrinsic helicase activity, MCM9 interacts with MCM8 to form a functional complex that promotes DNA end resection and strand invasion during homologous recombination. It also associates with replication proteins such as RPA and RAD51, coordinating DNA repair with replication fork progression.
The MCM9 antibody is widely used in cell cycle, DNA repair, and cancer research to study replication licensing, recombination mechanisms, and genome maintenance. Western blot analysis detects a 130 kilodalton band corresponding to MCM9, while immunofluorescence shows distinct nuclear foci that colocalize with replication and repair markers. This antibody enables detailed analysis of DNA replication and damage response pathways.
Functionally, MCM9 is required for the recruitment of repair proteins to sites of DNA damage and for the restart of stalled replication forks. Mutations in MCM9 are associated with hereditary colorectal cancer syndromes and premature ovarian failure due to impaired DNA repair capacity. Loss of MCM9 function results in genomic instability and sensitivity to DNA-damaging agents. The MCM9 antibody provides a key reagent for investigating replication integrity, homologous recombination, and tumor suppression mechanisms. NSJ Bioreagents validates this antibody for its applications, ensuring accurate and reproducible detection for genome stability studies. -
UniProt
- Q9NXL9
抗原
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