MYB 抗体 (AA 1-590)
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Quick Overview for MYB 抗体 (AA 1-590) (ABIN7869488)
抗原
See all MYB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-590
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原理
- Zebrafish c-Myb Antibody / Myb
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish C-myb recombinant protein (amino acids M1-I590) was used as the immunogen for the Zebrafish C-myb antibody.
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亚型
- Ig Fraction
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应用备注
- Optimal dilution of the Zebrafish C-myb antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish C-myb antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))
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别名
- c-Myb
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背景
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C-Myb is a transcription factor that plays a critical role in the regulation of gene expression during the development and maintenance of hematopoietic stem and progenitor cells. In zebrafish, c-Myb is essential for the formation of definitive blood cells and is widely used as a marker of early hematopoiesis.
During zebrafish embryogenesis, c-Myb is expressed in the dorsal aorta, where hematopoietic stem cells first emerge, as well as in the developing thymus and other hematopoietic tissues. It regulates the expression of genes involved in cell proliferation, differentiation, and survival. Loss of c-Myb function leads to defects in blood cell development, particularly in the production of lymphoid and myeloid lineages.
Due to its conserved function in vertebrate hematopoiesis, zebrafish c-Myb is commonly used in research focused on blood development, leukemia, stem cell biology, and gene regulation. Its accessibility in zebrafish models allows for detailed in vivo studies of hematopoietic disorders and drug screening applications.
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UniProt
- F1QP25
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途径
- Chromatin Binding, Positive Regulation of Immune Effector Process
抗原
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