RTKN2 抗体 (AA 1-572)
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Quick Overview for RTKN2 抗体 (AA 1-572) (ABIN7869483)
抗原
See all RTKN2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-572
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原理
- RTKN2 Antibody / Rhotekin 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human RTKN2 recombinant protein (Position: M1-D572) was used as the immunogen for the RTKN2 antibody.
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亚型
- IgG
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anti-Rhotekin 2 (RTKN2) (AA 1-163) antibody
RTKN2 适用: 人 ELISA, WB, IHC (p) 宿主: 小鼠 Monoclonal 2C2 unconjugated
anti-Rhotekin 2 (RTKN2) (AA 1-163) antibodyRTKN2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Rhotekin 2 (RTKN2) (AA 1-163) antibodyRTKN2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Rhotekin 2 (RTKN2) (AA 1-164) antibodyRTKN2 适用: 人 ELISA, WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2C2 unconjugated
anti-Rhotekin 2 (RTKN2) antibodyRTKN2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Rhotekin 2 (RTKN2) (AA 99-127), (N-Term) antibodyRTKN2 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB27444 unconjugated
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应用备注
- Optimal dilution of the RTKN2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the RTKN2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- RTKN2 (Rhotekin 2 (RTKN2))
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别名
- RTKN2
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背景
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RTKN2 antibody detects Rhotekin 2, a Rho GTPase effector protein that regulates cytoskeletal dynamics, apoptosis, and immune cell signaling. The UniProt recommended name is Rhotekin 2 (RTKN2). This protein acts as a scaffold for RhoA-mediated signaling pathways that control actin organization, transcriptional activity, and cell survival.
Functionally, RTKN2 antibody identifies a 646-amino-acid cytoplasmic protein containing a Rho-binding domain (RBD) and ankyrin repeats that mediate protein-protein interactions. RTKN2 binds active GTP-bound RhoA to stabilize cytoskeletal structures and prevent apoptotic signaling. It also influences NF-kappaB activation and transcriptional regulation of immune and inflammatory genes. In T lymphocytes, RTKN2 promotes cell survival and proliferation by integrating RhoA and anti-apoptotic signaling pathways.
The RTKN2 gene is located on chromosome 10q21.1 and is highly expressed in lymphoid tissues, testis, and brain. Expression increases during T-cell activation and stress responses, indicating roles in immune signaling and cytoskeletal adaptation. RTKN2 contributes to both structural stability and signaling plasticity within dynamic cellular environments.
Pathologically, RTKN2 has been implicated in cancer and autoimmune disease. Overexpression enhances survival and proliferation of cancer cells through activation of NF-kappaB and suppression of apoptosis, whereas reduced RTKN2 expression may impair lymphocyte function and stress resistance. Research using RTKN2 antibody supports studies in Rho GTPase signaling, cytoskeletal dynamics, and immune cell regulation.
RTKN2 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect Rho effector proteins. NSJ Bioreagents provides RTKN2 antibody reagents optimized for research in signal transduction, apoptosis regulation, and cytoskeletal remodeling.
Structurally, Rhotekin 2 consists of a central RhoA-binding domain, ankyrin repeats, and multiple phosphorylation sites that control its localization and interaction with downstream effectors. Its structure enables binding to GTP-bound RhoA and integration with cell survival pathways. This antibody facilitates analysis of RTKN2's role in Rho-dependent signaling and immune cell function. -
UniProt
- Q8IZC4
抗原
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