WBSCR17 抗体 (AA 1-558)
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Quick Overview for WBSCR17 抗体 (AA 1-558) (ABIN7869471)
抗原
See all WBSCR17 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-558
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原理
- GALNT16 Antibody / Polypeptide N-acetylgalactosaminyltransferase 16
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human GALNT16 recombinant protein (Position: M1-T558) was used as the immunogen for the GALNT16 antibody.
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亚型
- IgG
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anti-Williams-Beuren Syndrome Chromosome Region 17 (WBSCR17) (AA 101-300) antibody
WBSCR17 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Williams-Beuren Syndrome Chromosome Region 17 (WBSCR17) (AA 301-558) antibodyWBSCR17 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Williams-Beuren Syndrome Chromosome Region 17 (WBSCR17) (AA 411-440), (C-Term) antibodyWBSCR17 适用: 小鼠 WB 宿主: 兔 Polyclonal RB32657 unconjugated
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应用备注
- Optimal dilution of the GALNT16 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GALNT16 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- WBSCR17 (Williams-Beuren Syndrome Chromosome Region 17 (WBSCR17))
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别名
- GALNT16
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背景
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GALNT16 antibody detects Polypeptide N-acetylgalactosaminyltransferase 16, a glycosyltransferase responsible for initiating mucin-type O-linked glycosylation of proteins. Encoded by the GALNT16 gene on chromosome 14q24.3, this enzyme belongs to the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family and catalyzes the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to serine or threonine residues of target proteins, forming the Tn antigen. GALNT16 participates in glycoprotein biosynthesis critical for cell signaling, adhesion, and extracellular communication.
Structurally, GALNT16 contains a catalytic domain responsible for GalNAc transferase activity and a C-terminal ricin-like lectin domain that enhances substrate recognition. It exhibits unique substrate specificity, preferentially modifying glycoproteins involved in neuronal signaling, epithelial maintenance, and immune responses. GALNT16 localizes to the Golgi apparatus, consistent with its function in post-translational modification and protein trafficking.
The GALNT16 antibody is widely used in glycobiology, cancer, and neurobiology research to investigate O-glycosylation pathways and their role in cellular communication. Western blot analysis identifies a 64 kilodalton band corresponding to GALNT16, while immunofluorescence reveals Golgi-localized perinuclear staining. This antibody provides a valuable tool for studying differential glycosylation patterns and their impact on protein stability and cell signaling.
Altered GALNT16 expression has been observed in cancers, where changes in O-glycosylation influence tumor cell invasion and immune evasion. Its expression in brain tissue also suggests involvement in synaptic regulation and neurodevelopment. The GALNT16 antibody enables exploration of how glycosylation controls key biological processes in health and disease. NSJ Bioreagents validates this antibody for its applications, ensuring reliability for glycosylation and protein modification studies. -
UniProt
- Q8N428
抗原
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