NPLOC4 抗体 (AA 1-510)
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Quick Overview for NPLOC4 抗体 (AA 1-510) (ABIN7869444)
抗原
See all NPLOC4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-510
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原理
- Zebrafish Nploc4 Antibody / Npl4 / Nuclear protein localization protein 4
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Nploc4 recombinant protein (amino acids M1-C510) was used as the immunogen for the Zebrafish Nploc4 antibody.
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亚型
- Ig Fraction
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anti-Nuclear Protein Localization 4 Homolog (NPLOC4) (AA 1-270) antibody
NPLOC4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Protein Localization 4 Homolog (NPLOC4) (AA 1-608) antibodyNPLOC4 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Protein Localization 4 Homolog (NPLOC4) (AA 1-608) antibodyNPLOC4 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Nuclear Protein Localization 4 Homolog (NPLOC4) (AA 96-145) antibodyNPLOC4 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Protein Localization 4 Homolog (NPLOC4) (AA 456-484), (C-Term) antibodyNPLOC4 适用: 人 WB 宿主: 兔 Polyclonal RB37356 unconjugated
anti-Nuclear Protein Localization 4 Homolog (NPLOC4) (AA 1-495) antibodyNPLOC4 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Zebrafish Nploc4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Nploc4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- NPLOC4 (Nuclear Protein Localization 4 Homolog (NPLOC4))
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别名
- Nploc4
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背景
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Nploc4, or nuclear protein localization protein four homolog, is a highly conserved protein involved in protein degradation and cellular stress response pathways. It acts as a cofactor in the disassembly of polyubiquitinated protein complexes, particularly in cooperation with the ATPase p97 also known as VCP. Nploc4 plays an essential role in extracting ubiquitinated substrates from membranes and protein complexes to facilitate their degradation by the proteasome.
In zebrafish, Nploc4 is expressed in multiple tissues and is especially active in proliferative or metabolically active cells. The zebrafish Nploc4 protein is an ortholog of the human NPLOC4 gene. Both versions of the protein share strong sequence and functional conservation, indicating that zebrafish can serve as a reliable model for studying NPLOC4 related biology.
Functionally, Nploc4 is part of a complex with Ufd1 and p97, and this complex is critical for endoplasmic reticulum associated degradation, chromatin remodeling, and cell cycle regulation. Disruption of Nploc4 function in zebrafish leads to defects in protein homeostasis and developmental abnormalities, especially in systems that are sensitive to proteotoxic stress such as the nervous system and musculature.
Given its central role in maintaining cellular protein quality control and its conservation with human NPLOC4, zebrafish Nploc4 is commonly used in developmental studies and disease models related to protein aggregation, neurodegeneration, and cellular stress adaptation.
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UniProt
- Q7ZVI8
抗原
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