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RORC 抗体 (AA 1-50)

The 小鼠 单克隆 anti-RORC antibody is suitable to detect RORC in samples from 人. It has been validated for ELISA.
产品编号 ABIN7869423
发货至: 中国
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Quick Overview for RORC 抗体 (AA 1-50) (ABIN7869423)

抗原

See all RORC 抗体
RORC (RAR-Related Orphan Receptor C (RORC))

适用

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宿主

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小鼠

克隆类型

  • 91
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单克隆

标记

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This RORC antibody is un-conjugated

应用范围

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ELISA

克隆位点

RORC-2942
  • 抗原表位

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    AA 1-50

    原理

    RORC Antibody

    纯化方法

    Protein G affinity chromatography

    免疫原

    Recombinant human RORC protein was used as the immunogen for the RORC antibody. The epitope has been found to be with amino acids 1-50.

    亚型

    IgG2a, kappa
  • 应用备注

    Optimal dilution of the RORC antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store the RORC antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    RORC (RAR-Related Orphan Receptor C (RORC))

    别名

    RORC

    背景

    This MAb recognizes a protein of 63 kDa, identified as ROR-C. Its epitope maps in between aa1-50. The nuclear orphan receptors ROR and ROR are members of the nuclear hormone receptor superfamily. Members of this family act by directly associating with DNA sequences known as hormone response elements (HREs) and typically bind DNA as either homo- or heterodimers. RORalpha and RORgamma are unique in that they bind DNA as monomers. RORalpha has multiple isoforms that share common DNA and putative ligand-binding domains, but differ in their amino terminal domains, which are generated by alternative RNA processing. RORgamma comprises a 560 amino acid protein that shares 50 % amino acid identity with RORalpha and is most highly expressed in skeletal muscle. Although these proteins are considered orphan receptors, due to a lack of defined ligands, experimental evidence has shown that melatonin may be the natural ligand for these nuclear receptors.

    UniProt

    P51449

    途径

    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
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