SOX9 抗体 (AA 1-496)
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Quick Overview for SOX9 抗体 (AA 1-496) (ABIN7869416)
抗原
See all SOX9 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-496
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原理
- SOX9 Antibody / SRY-box transcription factor 9
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SOX9 recombinant protein (Position: M1-Q496) was used as the immunogen for the SOX9 antibody.
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亚型
- IgG
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anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) (AA 400-509) antibody
SOX9 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 3C10 unconjugated
anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) (AA 393-508) antibodySOX9 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal SOX9-2387 unconjugated
anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) antibodyKD Validated SOX9 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 24GB2000 unconjugated Recombinant Antibody
anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) (AA 400-509) antibodySOX9 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3F11 unconjugated
anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) (pSer181) antibodySOX9 适用: 人, 小鼠, 小鸡 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) antibodySOX9 适用: 人 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 1B11 unconjugated
anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) (C-Term) antibodySOX9 适用: 人, 小鼠, 大鼠, 兔, 犬, Pig, Cow, 豚鼠, 斑马鱼, 马 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) (AA 41-70) antibodySOX9 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) (AA 121-220) antibodySOX9 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) (AA 400-510) antibodySOX9 适用: 人 WB, IHC, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3C10 unconjugated
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应用备注
- Optimal dilution of the SOX9 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SOX9 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SOX9 (SRY (Sex Determining Region Y)-Box 9 (SOX9))
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别名
- SOX9
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背景
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SOX9 antibody detects SRY-box transcription factor 9, a transcriptional regulator that controls chondrogenesis, sex determination, and stem cell maintenance. The UniProt recommended name is SRY-box transcription factor 9 (SOX9). This protein belongs to the SOX (SRY-related HMG-box) family of transcription factors, characterized by a high-mobility group DNA-binding domain that recognizes specific enhancer sequences.
Functionally, SOX9 antibody identifies a 509-amino-acid nuclear protein that binds to promoter and enhancer regions of cartilage-specific genes such as COL2A1 and ACAN. SOX9 forms dimers through its HMG domain and recruits transcriptional coactivators to drive cartilage matrix production and skeletal formation. It also plays roles in sex differentiation by activating AMH (anti-Mi 1/2llerian hormone) transcription during gonadal development.
The SOX9 gene is located on chromosome 17q24.3 and is expressed in developing cartilage, gonads, and neural crest-derived tissues. SOX9 is a master regulator of chondrocyte differentiation and is essential for maintaining progenitor cell identity in multiple lineages.
Pathologically, mutations or haploinsufficiency of SOX9 cause campomelic dysplasia, a severe skeletal malformation syndrome with sex reversal. Aberrant SOX9 expression also contributes to cancer progression and tissue fibrosis. Research using SOX9 antibody supports studies in developmental biology, transcription regulation, and regenerative medicine.
SOX9 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect transcription factors involved in chondrogenesis and lineage specification. NSJ Bioreagents provides SOX9 antibody reagents optimized for studies in cartilage biology, stem cell differentiation, and developmental genetics.
Structurally, SRY-box transcription factor 9 contains an HMG DNA-binding domain and transactivation regions that mediate chromatin remodeling and transcriptional activation. This antibody supports detailed analysis of SOX9's regulatory mechanisms in development and disease. -
UniProt
- P48436
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途径
- EGFR Signaling Pathway, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
抗原
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