Recombinant Tryptophan Hydroxylase 2 抗体 (AA 1-490)
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Quick Overview for Recombinant Tryptophan Hydroxylase 2 抗体 (AA 1-490) (ABIN7869410)
抗原
See all Tryptophan Hydroxylase 2 (TPH2) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-490
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原理
- TPH2 Antibody / Tryptophan hydroxylase 2
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纯化方法
- Affinity chromatography
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免疫原
- Recombinant protein with human THP2 (Position: M1-I490) was used as the immunogen for the TPH2 antibody.
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亚型
- IgG
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anti-Tryptophan Hydroxylase 2 (TPH2) (Internal Region) antibody
Verified TPH2 适用: 人 ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Tryptophan Hydroxylase 2 (TPH2) (AA 44-225) antibodyTPH2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tryptophan Hydroxylase 2 (TPH2) antibodyMicroarray verified TPH2 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB425277 unconjugated
anti-Tryptophan Hydroxylase 2 (TPH2) (AA 1-170) antibodyTPH2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Tryptophan Hydroxylase 2 (TPH2) antibodyMicroarray verified TPH2 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB822648 unconjugated
anti-Tryptophan Hydroxylase 2 (TPH2) (AA 168-193) antibodyTPH2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22900 unconjugated
anti-Tryptophan Hydroxylase 2 (TPH2) (AA 16-29) antibodyVerified TPH2 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Tryptophan Hydroxylase 2 (TPH2) (Internal Region) antibodyVerified TPH2 适用: 小鼠 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Tryptophan Hydroxylase 2 (TPH2) antibodyMicroarray verified TPH2 适用: 人 IHC 宿主: 小鼠 Monoclonal MAB26484 unconjugated
anti-Tryptophan Hydroxylase 2 (TPH2) antibodyMicroarray verified TPH2 适用: 人 IHC 宿主: 小鼠 Monoclonal MAB282025 unconjugated
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应用备注
- Optimal dilution of the TPH2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the TPH2 antibody at -20oC.
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- Tryptophan Hydroxylase 2 (TPH2)
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别名
- TPH2
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背景
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TPH2 antibody detects Tryptophan hydroxylase 2, encoded by the TPH2 gene. Tryptophan hydroxylase 2 is the rate limiting enzyme in the biosynthesis of serotonin in the brain. By catalyzing the hydroxylation of tryptophan to 5 hydroxytryptophan, which is then decarboxylated to serotonin, this enzyme plays an essential role in neurotransmission, mood regulation, and circadian rhythms. TPH2 antibody provides researchers with a vital tool to study serotonin metabolism, neuronal signaling, and psychiatric disorders.
Tryptophan hydroxylase 2 is distinct from TPH1, which performs the same enzymatic reaction but is expressed primarily in peripheral tissues. TPH2 is enriched in serotonergic neurons of the raphe nuclei in the brainstem. Research with TPH2 antibody has revealed that disruption of this enzyme reduces central serotonin production, leading to alterations in behavior, mood, and stress responses. This central role has made TPH2 a focus of studies in depression, anxiety, and other mood disorders.
Mutations in TPH2 have been associated with psychiatric disease and developmental disorders. Genetic variants that reduce enzyme activity have been linked to susceptibility to depression, bipolar disorder, and autism spectrum disorders. Studies using TPH2 antibody in postmortem brain tissue have confirmed altered expression in individuals with psychiatric conditions, supporting its clinical relevance. Animal models with disrupted TPH2 expression also display behavioral phenotypes, reinforcing the causal role of this enzyme in serotonin dependent pathways.
Beyond psychiatry, TPH2 is relevant in circadian biology, stress physiology, and drug response. Serotonin produced by TPH2 serves as a precursor for melatonin synthesis in the pineal gland, linking it to circadian regulation. Research with TPH2 antibody has shown that stress hormones modulate its expression, suggesting integration of environmental cues with neurotransmitter metabolism. Because many antidepressants and antipsychotics target serotonin pathways, TPH2 remains an important pharmacological research target.
TPH2 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting measures enzyme levels in brain lysates, immunohistochemistry demonstrates expression in raphe nuclei and other serotonergic structures, and immunofluorescence allows visualization of neuronal localization. These methods make TPH2 antibody indispensable in neuroscience research.
By providing validated TPH2 antibody reagents, NSJ Bioreagents supports research into neurotransmitter metabolism, brain development, and psychiatric disease. Detection of Tryptophan hydroxylase 2 provides researchers with a reliable means to study serotonin pathways in health and disease. -
UniProt
- Q8IWU9
抗原
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