ADC 抗体 (AA 1-448)
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Quick Overview for ADC 抗体 (AA 1-448) (ABIN7869374)
抗原
See all ADC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-448
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原理
- Antizyme inhibitor 2 Antibody / AZIN2 / Arginine decarboxylase
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids M1-L448) was used as the immunogen for the Antizyme inhibitor 2 antibody.
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亚型
- IgG
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anti-Arginine Decarboxylase (ADC) (AA 111-301) antibody
ADC 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Arginine Decarboxylase (ADC) (AA 1-448) antibodyADC 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Arginine Decarboxylase (ADC) (AA 51-150) antibodyADC 适用: 人, 小鼠, 大鼠 WB, IF (cc), IF (p), IHC (p), ELISA, IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Arginine Decarboxylase (ADC) (AA 179-228) antibodyADC 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, Pig, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Arginine Decarboxylase (ADC) (Middle Region) antibodyADC 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 兔, Cow, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Antizyme inhibitor 2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Antizyme inhibitor 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- ADC (Arginine Decarboxylase (ADC))
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别名
- Antizyme inhibitor 2
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背景
- Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine, however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.
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UniProt
- Q96A70
抗原
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