MAZ 抗体 (AA 1-430)
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Quick Overview for MAZ 抗体 (AA 1-430) (ABIN7869353)
抗原
See all MAZ 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-430
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原理
- MAZ Antibody / Myc associated zinc finger protein
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human MAZ recombinant protein (Position: M1-E430) was used as the immunogen for the MAZ antibody.
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亚型
- IgG
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anti-MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ) (AA 332-440) antibody
MAZ 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3D2 unconjugated
anti-MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ) (N-Term) antibodyMAZ 适用: 人, 小鼠, 大鼠, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ) (AA 30-80) antibodyMAZ 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ) (N-Term) antibodyMAZ 适用: 人, 小鼠, 大鼠, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ) (N-Term) antibodyMAZ 适用: 人, 小鼠, 大鼠, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ) (AA 1-264) antibodyMAZ 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F3 unconjugated
anti-MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ) (AA 332-440) antibodyMAZ 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6G2 unconjugated
anti-MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ) (AA 427-477) antibodyMAZ 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ) antibodyMAZ 适用: 人 WB, ChIP, SSA 宿主: 小鼠 Monoclonal 133 unconjugated
anti-MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ) (AA 295-327) antibodyMAZ 适用: 人 WB 宿主: 兔 Polyclonal RB53652 unconjugated
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应用备注
- Optimal dilution of the MAZ antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MAZ antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MAZ (MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ))
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别名
- MAZ
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背景
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MAZ antibody detects Myc associated zinc finger protein, encoded by the MAZ gene. Myc associated zinc finger protein is a transcription factor that regulates gene expression through GC-rich DNA elements and is involved in cell growth, apoptosis, and oncogenesis. MAZ antibody provides researchers with a critical reagent for studying transcriptional regulation and cancer biology.
Myc associated zinc finger protein belongs to the Kruppel family of zinc finger proteins and contains six C2H2-type zinc fingers. Research using MAZ antibody has shown that it binds to GC-rich promoter elements and initiator regions, where it regulates transcription of a wide range of genes. These include c-Myc, VEGF, and insulin receptor genes, linking MAZ to proliferation, angiogenesis, and metabolism.
Studies with MAZ antibody have revealed that the protein has dual transcriptional roles, functioning as both an activator and repressor depending on context. It recruits transcriptional co-regulators and chromatin remodelers, fine-tuning expression of growth-related genes. This versatility makes MAZ a central node in transcriptional networks controlling development and disease.
Dysregulation of Myc associated zinc finger protein has been associated with cancer, cardiovascular disease, and neurodegeneration. Research using MAZ antibody has shown that overexpression promotes tumor growth and angiogenesis by upregulating VEGF and c-Myc. It has also been implicated in atherosclerosis, where it regulates vascular smooth muscle proliferation, and in neurodegenerative disorders, where altered transcription contributes to pathology.
MAZ antibody is commonly used in chromatin immunoprecipitation, western blotting, and immunohistochemistry. Chromatin immunoprecipitation identifies promoter binding sites, western blotting quantifies expression in normal and cancer tissues, and immunohistochemistry demonstrates nuclear localization in proliferating cells. These applications make MAZ antibody valuable for transcriptional and oncogenesis research.
By supplying validated MAZ antibody reagents, NSJ Bioreagents supports studies into transcriptional control, oncogenesis, and vascular biology. Detection of Myc associated zinc finger protein provides researchers with insight into how zinc finger proteins regulate gene expression and disease. -
UniProt
- P56270
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途径
- Chromatin Binding
抗原
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