GAS7 抗体 (AA 1-421)
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北京 101111
Quick Overview for GAS7 抗体 (AA 1-421) (ABIN7869341)
抗原
See all GAS7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-421
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原理
- GAS7 Antibody / Growth arrest-specific protein 7
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human GAS7 recombinant protein (Position: M1-Q421) was used as the immunogen for the GAS7 antibody.
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亚型
- IgG
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anti-Growth Arrest-Specific 7 (GAS7) antibody
GAS7 适用: 人, 大鼠, 犬 WB, IHC, FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal 2F6 unconjugated
anti-Growth Arrest-Specific 7 (GAS7) (AA 438-465), (C-Term) antibodyGAS7 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20062 unconjugated
anti-Growth Arrest-Specific 7 (GAS7) (AA 1-153) antibodyGAS7 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest-Specific 7 (GAS7) antibodyGAS7 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest-Specific 7 (GAS7) (AA 1-416) antibodyGAS7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Arrest-Specific 7 (GAS7) (AA 118-167) antibodyGAS7 适用: 人, 犬, Cow, 豚鼠, 马, 兔, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest-Specific 7 (GAS7) (AA 1-412) antibodyGAS7 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest-Specific 7 (GAS7) (N-Term) antibodyGAS7 适用: 人, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest-Specific 7 (GAS7) antibodyGAS7 适用: 人, 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest-Specific 7 (GAS7) antibodyGAS7 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GAS7 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GAS7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GAS7 (Growth Arrest-Specific 7 (GAS7))
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别名
- GAS7
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背景
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GAS7 antibody detects Growth arrest-specific protein 7, a cytoskeletal and signaling adapter protein involved in neuronal differentiation, cytoskeletal organization, and cell growth regulation. Encoded by the GAS7 gene on chromosome 17p13.1, this protein is part of the growth arrest-specific (GAS) gene family that is induced during cell cycle arrest. GAS7 contains WW and F-BAR domains that enable membrane deformation and actin cytoskeleton remodeling, supporting neurite outgrowth and cell shape changes. It is highly expressed in the nervous system, particularly in developing neurons and the cerebral cortex.
GAS7 acts as a structural and regulatory protein linking signaling pathways to cytoskeletal remodeling. Its F-BAR domain promotes membrane tubulation and extension of cellular processes, while its WW domain mediates interaction with proline-rich signaling proteins. GAS7 facilitates neurite initiation and elongation by coordinating actin and microtubule dynamics. In non-neuronal cells, it contributes to growth arrest and differentiation through modulation of cytoskeletal tension. Its expression is upregulated during cell cycle exit and differentiation, suggesting a role in maintaining terminal cell identity.
The GAS7 antibody is used in neurobiology, developmental, and cancer research to detect Growth arrest-specific protein 7 expression and localization. Western blot analysis typically identifies a 48 kilodalton band, while immunofluorescence shows cytoplasmic and membrane-associated staining consistent with its role in actin remodeling. GAS7 is also studied for its involvement in leukemia, where chromosomal translocations involving GAS7 and transcription factors such as EWSR1 have been identified, indicating potential roles in oncogenic fusion gene formation.
Beyond neuronal function, GAS7 is expressed in macrophages and fibroblasts where it regulates cell spreading, migration, and vesicle trafficking. The GAS7 antibody supports research into cytoskeletal signaling and differentiation control, particularly in studies of neuronal morphogenesis and actin network dynamics. NSJ Bioreagents provides this antibody validated for its applications, ensuring reliable detection of GAS7 across a range of tissues and model systems -
UniProt
- O60861
抗原
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