STYK1 抗体 (AA 1-404)
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北京 101111
Quick Overview for STYK1 抗体 (AA 1-404) (ABIN7869322)
抗原
See all STYK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-404
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原理
- STYK1 Antibody / Serine/threonine/tyrosine kinase 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human STYK1 recombinant protein (Position: M1-Y404) was used as the immunogen for the STYK1 antibody.
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亚型
- IgG
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anti-serine/threonine/tyrosine Kinase 1 (STYK1) (AA 50-159) antibody
STYK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D2 unconjugated
anti-serine/threonine/tyrosine Kinase 1 (STYK1) (AA 1-422) antibodySTYK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine/tyrosine Kinase 1 (STYK1) (AA 1-422) antibodySTYK1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine/tyrosine Kinase 1 (STYK1) (AA 50-159) antibodySTYK1 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 3A8 unconjugated
anti-serine/threonine/tyrosine Kinase 1 (STYK1) antibodySTYK1 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 2H2F10 unconjugated
anti-serine/threonine/tyrosine Kinase 1 (STYK1) (AA 51-150) antibodySTYK1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine/tyrosine Kinase 1 (STYK1) (AA 1-422) antibodySTYK1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-serine/threonine/tyrosine Kinase 1 (STYK1) (AA 31-64), (N-Term) antibodySTYK1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB9197 unconjugated
anti-serine/threonine/tyrosine Kinase 1 (STYK1) (C-Term) antibodySTYK1 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, Cow, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine/tyrosine Kinase 1 (STYK1) (C-Term) antibodySTYK1 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the STYK1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the STYK1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- STYK1 (serine/threonine/tyrosine Kinase 1 (STYK1))
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别名
- STYK1
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背景
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STYK1 antibody detects Serine/threonine/tyrosine kinase 1, a membrane-associated receptor-like kinase implicated in cell growth, migration, and tumor progression. Encoded by the STYK1 gene on chromosome 12q24.13, this atypical kinase belongs to the receptor protein tyrosine kinase family but exhibits dual-specificity catalytic activity, phosphorylating both serine/threonine and tyrosine residues. STYK1 functions in intracellular signaling pathways that regulate proliferation, differentiation, and oncogenic transformation.
Structurally, STYK1 is composed of a short extracellular domain, a single transmembrane helix, and a cytoplasmic kinase domain that mediates signal transduction. Although structurally similar to receptor tyrosine kinases, it lacks a classical ligand-binding domain and likely operates through intracellular signaling or interaction with other membrane proteins. STYK1 activates downstream effectors, including the MAPK/ERK and PI3K/AKT pathways, promoting cell survival and motility.
The STYK1 antibody is widely used in cancer biology, kinase signaling, and molecular pathology research to investigate its oncogenic potential and functional roles in signal integration. Western blot analysis detects a 48 kilodalton band corresponding to STYK1, while immunohistochemistry shows strong membrane and cytoplasmic staining in epithelial tissues and cancer cells. This antibody provides a sensitive tool for evaluating kinase expression patterns and activation states in tumor and normal tissues.
Overexpression of STYK1 has been documented in lung, breast, prostate, and ovarian cancers, where it enhances tumor cell proliferation, metastasis, and resistance to apoptosis. It may function as a pseudokinase or a signaling scaffold that amplifies receptor-mediated responses. In normal physiology, STYK1 contributes to embryonic development and tissue regeneration by regulating kinase cross-talk. The STYK1 antibody enables researchers to dissect these mechanisms and explore its potential as a therapeutic target in oncology. NSJ Bioreagents validates this antibody for western blotting, immunohistochemistry, and immunofluorescence, ensuring high-quality and reproducible detection for kinase signaling research. -
UniProt
- Q6J9G0
抗原
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