PPP1R12A 抗体 (AA 1-40)
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Quick Overview for PPP1R12A 抗体 (AA 1-40) (ABIN7869302)
抗原
See all PPP1R12A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-40
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原理
- Zebrafish Ppp1r12a Antibody / Mypt1
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Ppp1r12a recombinant protein (amino acids M1-D40) was used as the immunogen for the Zebrafish Ppp1r12a antibody.
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亚型
- Ig Fraction
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anti-Myosin Phosphatase, Target Subunit 1 (PPP1R12A) (C-Term) antibody
Verified PPP1R12A 适用: 人 IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Myosin Phosphatase, Target Subunit 1 (PPP1R12A) (AA 1-200) antibodyPPP1R12A 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Myosin Phosphatase, Target Subunit 1 (PPP1R12A) (AA 1-40), (N-Term) antibodyPPP1R12A 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myosin Phosphatase, Target Subunit 1 (PPP1R12A) (C-Term) antibodyPPP1R12A 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Myosin Phosphatase, Target Subunit 1 (PPP1R12A) (pThr696) antibodyPPP1R12A 适用: 人, 大鼠 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-Myosin Phosphatase, Target Subunit 1 (PPP1R12A) (AA 481-514), (Ser507) antibodyPPP1R12A 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB56872 unconjugated
anti-Myosin Phosphatase, Target Subunit 1 (PPP1R12A) (AA 710-970) antibodyPPP1R12A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myosin Phosphatase, Target Subunit 1 (PPP1R12A) (pThr853) antibodyPPP1R12A 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Myosin Phosphatase, Target Subunit 1 (PPP1R12A) (pThr853) antibodyPPP1R12A 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Myosin Phosphatase, Target Subunit 1 (PPP1R12A) (pThr696) antibodyPPP1R12A 适用: 人, 小鼠, 大鼠, 斑马鱼, 小鸡, Pig WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Zebrafish Ppp1r12a antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Ppp1r12a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
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别名
- Ppp1r12a
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背景
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Ppp1r12a, or protein phosphatase one regulatory subunit twelve a, is a regulatory protein that controls the activity of protein phosphatase one, a major serine threonine phosphatase involved in numerous cellular processes. In zebrafish, Ppp1r12a plays a critical role in regulating cytoskeletal organization, cell contractility, and morphogenesis during development.
Zebrafish Ppp1r12a is the ortholog of the human PPP1R12A gene, which encodes the protein also known as myosin phosphatase target subunit one. This protein directs protein phosphatase one to myosin light chains and other cytoskeletal targets, enabling dynamic control of actomyosin contraction and cell movement. It is involved in signaling pathways that govern smooth muscle relaxation, cell shape changes, and cell migration.
During zebrafish development, Ppp1r12a is expressed in tissues undergoing active morphogenetic movements and structural rearrangement, such as the developing somites, neural tube, and heart. It contributes to proper tissue organization by regulating the phosphorylation state of cytoskeletal components and by modulating mechanical tension within cells.
Disruption of Ppp1r12a function in zebrafish has been shown to affect cell adhesion, motility, and organ formation, highlighting its importance in developmental processes. Due to its conservation across vertebrates and its central role in regulating phosphatase activity, zebrafish Ppp1r12a is a useful model for studying signal transduction, cytoskeletal regulation, and developmental disorders involving cell morphology and contractility.
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UniProt
- Q6DRG7
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途径
- M Phase
抗原
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