FOXI1 抗体 (AA 1-378)
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北京 101111
Quick Overview for FOXI1 抗体 (AA 1-378) (ABIN7869272)
抗原
See all FOXI1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-378
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原理
- FOXI1 Antibody / Forkhead box protein I1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human FOXI1 recombinant protein (Position: M1-V378) was used as the immunogen for the FOXI1 antibody.
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亚型
- IgG
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anti-Forkhead Box I1 (FOXI1) (AA 111-350) antibody
FOXI1 适用: 人 WB, IF, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 5D3 unconjugated
anti-Forkhead Box I1 (FOXI1) (AA 111-350) antibodyFOXI1 适用: 人 WB, IF, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 2C1 unconjugated
anti-Forkhead Box I1 (FOXI1) (AA 221-270) antibodyFOXI1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box I1 (FOXI1) (C-Term) antibodyVerified FOXI1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box I1 (FOXI1) (AA 111-350) antibodyFOXI1 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 7G9 unconjugated
anti-Forkhead Box I1 (FOXI1) (AA 1-283) antibodyFOXI1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Forkhead Box I1 (FOXI1) (AA 183-343) antibodyFOXI1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box I1 (FOXI1) (AA 20-69) antibodyFOXI1 适用: 人, 小鼠, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box I1 (FOXI1) (C-Term) antibodyFOXI1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box I1 (FOXI1) (AA 1-100) antibodyFOXI1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the FOXI1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the FOXI1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- FOXI1 (Forkhead Box I1 (FOXI1))
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别名
- FOXI1
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背景
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FOXI1 antibody targets Forkhead box protein I1, a member of the FOX family of transcription factors characterized by a conserved forkhead or 'winged helix' DNA-binding domain. The FOXI1 gene, located on chromosome 5q35.1, encodes a nuclear transcription factor that regulates ion transport and epithelial differentiation, particularly in the inner ear, kidney, and epididymis. FOXI1 controls expression of genes involved in acid-base balance and fluid homeostasis, including the vacuolar H+-ATPase subunit and pendrin (SLC26A4), a chloride/bicarbonate exchanger essential for maintaining luminal pH .
Structurally, FOXI1 contains a 110-amino acid forkhead domain that interacts with specific DNA motifs to modulate transcriptional activity. It functions as a transcriptional activator for genes expressed in intercalated cells of the distal nephron and cochlear epithelial cells. In the inner ear, FOXI1 contributes to endolymphatic ion transport and hearing development. In the kidney, loss of FOXI1 disrupts acid secretion, resulting in distal renal tubular acidosis (dRTA). Genetic mutations in FOXI1 have been linked to autosomal recessive dRTA and sensorineural hearing loss, demonstrating its dual role in renal and auditory physiology.
FOXI1 also participates in epithelial polarity regulation and may influence Wnt and Notch signaling pathways during organogenesis. Dysregulation of FOXI1 expression has been reported in certain cancers, where it may contribute to altered epithelial transport and cell differentiation. Functional studies suggest FOXI1 acts as a transcriptional regulator for ion transport proteins and can modulate developmental genes associated with morphogenesis of the ear and kidney.
Immunohistochemical staining using FOXI1 antibody reveals nuclear localization in renal intercalated cells, cochlear epithelium, and reproductive tissues. FOXI1 antibody from NSJ Bioreagents provides an essential reagent for research in transcriptional regulation, epithelial physiology, and hereditary renal and auditory disorders. -
UniProt
- Q12951
抗原
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