IFI44 抗体 (AA 1-370)
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北京 101111
Quick Overview for IFI44 抗体 (AA 1-370) (ABIN7869263)
抗原
See all IFI44 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-370
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原理
- IFI44 Antibody / Interferon induced protein 44
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived mouse IFI44 recombinant protein (Position: M1-H370) was used as the immunogen for the IFI44 antibody.
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亚型
- IgG
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anti-Interferon-Induced Protein 44 (IFI44) antibody
IFI44 适用: 人, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein 44 (IFI44) (AA 101-300) antibodyIFI44 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein 44 (IFI44) antibodyIFI44 适用: 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein 44 (IFI44) (AA 1-444) antibodyIFI44 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein 44 (IFI44) (AA 1-444) antibodyIFI44 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Interferon-Induced Protein 44 (IFI44) (AA 359-408) antibodyIFI44 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the IFI44 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the IFI44 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- IFI44 (Interferon-Induced Protein 44 (IFI44))
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别名
- IFI44
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背景
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IFI44 antibody detects Interferon-induced protein 44, encoded by the IFI44 gene on chromosome 1p31.1. IFI44 antibody is commonly used in immunology, antiviral, and autoimmune disease research. IFI44 is an interferon-stimulated gene product induced by type I interferons and viral infection. It contributes to the host antiviral defense response and is a biomarker of interferon pathway activation.
Structurally, IFI44 is a ~50 kDa protein with coiled-coil domains but lacks known catalytic motifs. It localizes predominantly to the cytoplasm, with potential mitochondrial and cytoskeletal associations. Its structure suggests a role as a scaffold or regulator rather than an enzyme.
Functionally, IFI44 is strongly induced by viral infections including influenza, hepatitis C virus, and SARS-CoV. It enhances innate immune responses, possibly by modulating cytoskeletal dynamics or mitochondrial function. Researchers use IFI44 antibody to study interferon responses, viral pathogenesis, and autoimmune disease mechanisms.
Clinically, IFI44 is elevated in autoimmune diseases such as systemic lupus erythematosus and dermatomyositis, where interferon signatures correlate with disease severity. It has been proposed as a diagnostic biomarker for interferon-driven conditions. IFI44 polymorphisms may also influence susceptibility to viral infections. NSJ Bioreagents provides IFI44 antibody to support immunology and infectious disease research.
Experimentally, IFI44 antibody is used in western blotting to detect the ~50 kDa protein, in immunohistochemistry to assess tissue expression, and in immunofluorescence to study cytoplasmic distribution. Transcriptomic studies often pair IFI44 expression with IFI44L to define interferon response signatures, and IFI44 antibody provides the protein-level validation. -
UniProt
- Q8BV66
抗原
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