Phospholamban 抗体 (AA 1-36)
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Quick Overview for Phospholamban 抗体 (AA 1-36) (ABIN7869249)
抗原
See all Phospholamban (PLN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-36
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原理
- PLB Antibody / Phospholamban / PLN
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids M1-C36) was used as the immunogen for the PLB antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the PLB antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PLB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Phospholamban (PLN)
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别名
- PLB
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背景
- Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. It is observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site.
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UniProt
- P26678
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途径
- Negative Regulation of Transporter Activity
抗原
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