CREB3 抗体 (AA 1-352)
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Quick Overview for CREB3 抗体 (AA 1-352) (ABIN7869239)
抗原
See all CREB3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-352
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原理
- CREB3 Antibody / Cyclic AMP-responsive element-binding protein 3
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human CREB3 recombinant protein (Position: M1-K352) was used as the immunogen for the CREB3 antibody.
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亚型
- IgG
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anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 273-371) antibody
CREB3 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 3H5 unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 1-230) antibodyCREB3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) antibodyCREB3 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 1-371) antibodyCREB3 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 1-230) antibodyCREB3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 311-344), (C-Term) antibodyCREB3 适用: 人 WB 宿主: 兔 Polyclonal RB50244 unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (C-Term) antibodyCREB3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 66-94), (N-Term) antibodyCREB3 适用: 人 WB 宿主: 兔 Polyclonal RB42213 unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) antibodyCREB3 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 76-87) antibodyVerified CREB3 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
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应用备注
- Optimal dilution of the CREB3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the CREB3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))
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别名
- CREB3
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背景
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CREB3 antibody detects Cyclic AMP-responsive element-binding protein 3, a transcription factor involved in the unfolded protein response and endoplasmic reticulum (ER) stress regulation. The UniProt recommended name is Cyclic AMP-responsive element-binding protein 3 (CREB3). This ER membrane-bound transcription factor controls gene expression related to protein folding, trafficking, and secretion.
Functionally, CREB3 antibody identifies a 371-amino-acid protein anchored in the ER membrane with a cytoplasmic basic leucine zipper (bZIP) domain. Upon ER stress, the N-terminal transcriptional domain of CREB3 is cleaved and translocated to the nucleus, where it activates target genes involved in secretion and Golgi maintenance. CREB3 also regulates acute phase response genes and collagen biosynthesis.
The CREB3 gene is located on chromosome 9p13.3 and is highly expressed in secretory tissues such as liver, pancreas, and intestine. It plays a central role in adapting to increased secretory load and maintaining ER homeostasis under stress conditions.
Pathologically, dysregulation of CREB3 contributes to metabolic disorders, neurodegeneration, and cancer progression by disturbing ER stress response pathways. Overexpression can enhance tumor invasion by modulating extracellular matrix and stress-related signaling genes. Research using CREB3 antibody supports studies in transcriptional regulation, ER stress, and secretory pathway biology.
CREB3 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect transcription factors and stress response regulators. NSJ Bioreagents provides CREB3 antibody reagents optimized for research in cellular homeostasis, transcription, and disease adaptation.
Structurally, Cyclic AMP-responsive element-binding protein 3 contains a bZIP domain for DNA binding and dimerization, along with a luminal stress-sensing region. This antibody enables investigation of CREB3's role in ER stress signaling and transcriptional control. -
UniProt
- O43889
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途径
- Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Maintenance of Protein Location, Unfolded Protein Response
抗原
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