NANS 抗体 (AA 1-341)
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Quick Overview for NANS 抗体 (AA 1-341) (ABIN7869220)
抗原
See all NANS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-341
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原理
- NANS Antibody / Sialic acid synthase
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human NANS recombinant protein (Position: M1-E341) was used as the immunogen for the NANS antibody.
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亚型
- IgG
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anti-N-Acetylneuraminic Acid Synthase (NANS) (AA 132-259) antibody
NANS 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-N-Acetylneuraminic Acid Synthase (NANS) (AA 260-359) antibodyNANS 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G6 unconjugated
anti-N-Acetylneuraminic Acid Synthase (NANS) (Center) antibodyNANS 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-N-Acetylneuraminic Acid Synthase (NANS) (AA 1-359) antibodyNANS 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-N-Acetylneuraminic Acid Synthase (NANS) antibodyNANS 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal AT1G6 unconjugated
anti-N-Acetylneuraminic Acid Synthase (NANS) (AA 1-359) antibodyNANS 适用: 人 WB, ELISA, IF, ICC 宿主: 小鼠 Monoclonal AT1G6 unconjugated
anti-N-Acetylneuraminic Acid Synthase (NANS) (AA 1-245) antibodyNANS 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal AT2E7 unconjugated
anti-N-Acetylneuraminic Acid Synthase (NANS) (AA 260-359) antibodyNANS 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-N-Acetylneuraminic Acid Synthase (NANS) antibodyNANS 适用: 人 WB, EIA 宿主: 小鼠 Monoclonal AT1G6 unconjugated
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应用备注
- Optimal dilution of the NANS antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the NANS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- NANS (N-Acetylneuraminic Acid Synthase (NANS))
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别名
- NANS
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背景
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The NANS antibody targets Sialic acid synthase, a cytosolic enzyme encoded by the NANS gene that catalyzes the formation of N-acetylneuraminic acid (Neu5Ac), the most abundant sialic acid in mammals. Sialic acids are terminal sugars found on glycoproteins and glycolipids, playing vital roles in cell-cell communication, pathogen recognition, and immune modulation. Sialic acid synthase converts N-acetylmannosamine-6-phosphate and phosphoenolpyruvate into N-acetylneuraminic acid-9-phosphate, which is later dephosphorylated to yield Neu5Ac. The NANS antibody enables precise detection of this enzyme, supporting research into glycosylation pathways, metabolic regulation, and genetic disease mechanisms.
Sialic acid synthase is widely expressed in tissues that actively produce glycoproteins, including liver, brain, and immune cells. The enzyme's activity is essential for the biosynthesis of sialylated glycoconjugates, which are critical for neuronal development and immune recognition. The NANS antibody allows researchers to monitor NANS expression levels and subcellular localization, facilitating studies that explore how sialic acid metabolism supports neural growth and synaptic function. In the developing brain, altered sialylation affects axonal targeting and synaptic plasticity, making this enzyme an important target in neurobiology.
Mutations in NANS cause sialic acid synthase deficiency, a rare autosomal recessive disorder characterized by skeletal dysplasia, developmental delay, and metabolic abnormalities. These mutations impair enzyme activity, leading to reduced sialic acid production and accumulation of precursors such as N-acetylmannosamine. The NANS antibody is an essential reagent for diagnosing and studying this deficiency, allowing direct measurement of protein levels and identification of loss-of-function variants. By detecting Sialic acid synthase in cellular and tissue models, researchers can examine how disrupted glycan biosynthesis contributes to disease phenotypes.
Beyond human pathology, Sialic acid synthase plays roles in host-pathogen interactions. Many viruses and bacteria exploit sialic acid residues for attachment and immune evasion. The NANS antibody helps elucidate how modulation of sialic acid synthesis influences infection susceptibility and immune responses. Additionally, this enzyme's regulation under hypoxia and stress conditions highlights its connection to energy metabolism and cellular adaptation.
The NANS antibody is suitable for western blotting, immunofluorescence, and immunohistochemistry. It yields strong cytoplasmic staining consistent with Sialic acid synthase localization. NSJ Bioreagents provides this antibody as a validated, high-specificity reagent for consistent results across applications. By enabling the study of glycan biosynthesis and metabolic signaling, the NANS antibody supports research in developmental biology, glycobiology, and metabolic disorders, helping clarify the essential role of sialic acid synthesis in human physiology. -
UniProt
- Q9NR45
抗原
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