TRIM44 抗体 (AA 1-332)
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Quick Overview for TRIM44 抗体 (AA 1-332) (ABIN7869203)
抗原
See all TRIM44 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-332
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原理
- TRIM44 Antibody / Tripartite motif-containing protein 44
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TRIM44 recombinant protein (Position: M1-E332) was used as the immunogen for the TRIM44 antibody.
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亚型
- IgG
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anti-Tripartite Motif Containing 44 (TRIM44) antibody
TRIM44 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E10 unconjugated
anti-Tripartite Motif Containing 44 (TRIM44) (Internal Region) antibodyTRIM44 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 44 (TRIM44) antibodyTRIM44 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 44 (TRIM44) (AA 1-344) antibodyTRIM44 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tripartite Motif Containing 44 (TRIM44) antibodyTRIM44 适用: 人 WB 宿主: 小鼠 Monoclonal 4A5 unconjugated
anti-Tripartite Motif Containing 44 (TRIM44) (C-Term) antibodyTRIM44 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, Pig, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 44 (TRIM44) (AA 107-156) antibodyTRIM44 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 44 (TRIM44) (AA 205-344) antibodyTRIM44 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 44 (TRIM44) (AA 298-327), (C-Term) antibodyTRIM44 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB37200 unconjugated
anti-Tripartite Motif Containing 44 (TRIM44) (Middle Region) antibodyTRIM44 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, Pig, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TRIM44 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TRIM44 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TRIM44 (Tripartite Motif Containing 44 (TRIM44))
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别名
- TRIM44
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背景
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TRIM44 antibody detects Tripartite motif-containing protein 44, an E3 ubiquitin ligase-like protein that regulates cell growth, stress response, and signaling through its role in ubiquitination and protein stabilization. Encoded by the TRIM44 gene on chromosome 11p13, this protein belongs to the tripartite motif (TRIM) family, characterized by a RING finger domain, B-box motifs, and a coiled-coil region that mediate protein-protein interactions. TRIM44 functions as a scaffold protein that influences autophagy, signal transduction, and oncogenic pathways by regulating substrate ubiquitination.
Structurally, TRIM44 is a 512-amino-acid cytoplasmic protein of approximately 57 kilodaltons containing a zinc-binding B-box and coiled-coil domains typical of TRIM proteins. Unlike many family members, TRIM44 lacks a canonical RING finger domain but instead contains a zinc metalloprotease-like region that mediates protein stabilization rather than degradation. This structural divergence enables TRIM44 to protect target proteins from proteasomal degradation, thereby modulating multiple signaling cascades including NF-?B and PI3K/AKT pathways.
The TRIM44 antibody is widely used in cancer biology, immunology, and cell signaling research to study ubiquitin-dependent protein regulation, tumor progression, and cellular stress response. Western blot analysis detects a 57 kilodalton band corresponding to TRIM44, while immunofluorescence shows cytoplasmic and perinuclear staining, reflecting its role in signaling and vesicular trafficking. This antibody provides a dependable reagent for investigating the molecular mechanisms by which TRIM44 regulates protein turnover and signal transduction.
Functionally, TRIM44 stabilizes key signaling proteins including mTOR and NF-?B regulators, promoting survival under stress conditions such as oxidative damage or nutrient deprivation. Overexpression of TRIM44 has been observed in multiple cancers including gastric, lung, and breast carcinomas, where it enhances proliferation, migration, and epithelial-mesenchymal transition (EMT). Conversely, its depletion sensitizes cells to apoptosis and autophagic degradation. The TRIM44 antibody supports research exploring ubiquitin signaling networks, autophagy regulation, and cancer-associated proteostasis. NSJ Bioreagents validates this antibody for its applications ensuring reproducible performance in cellular signaling and oncogenic pathway studies. -
UniProt
- Q96DX7
抗原
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