NAP1L4 抗体 (AA 1-331)
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Quick Overview for NAP1L4 抗体 (AA 1-331) (ABIN7869199)
抗原
See all NAP1L4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-331
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原理
- NAP1L4 Antibody / Nucleosome assembly protein 1-like 4
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human NAP1L4 recombinant protein (Position: M1-A331) was used as the immunogen for the NAP1L4 antibody.
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亚型
- IgG
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anti-Nucleosome Assembly Protein 1-Like 4 (NAP1L4) (AA 1-82) antibody
NAP1L4 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Nucleosome Assembly Protein 1-Like 4 (NAP1L4) (AA 89-138) antibodyNAP1L4 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Nucleosome Assembly Protein 1-Like 4 (NAP1L4) (N-Term) antibodyNAP1L4 适用: 人, 小鼠, 大鼠, 斑马鱼, Cow, 犬, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the NAP1L4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the NAP1L4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- NAP1L4 (Nucleosome Assembly Protein 1-Like 4 (NAP1L4))
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别名
- NAP1L4
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背景
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NAP1L4 antibody detects Nucleosome assembly protein 1-like 4, a histone chaperone involved in nucleosome assembly, chromatin remodeling, and transcriptional regulation. The UniProt recommended name is Nucleosome assembly protein 1-like 4 (NAP1L4). This protein belongs to the NAP1 family, which mediates histone transport and deposition during DNA replication and repair.
Functionally, NAP1L4 antibody identifies a 391-amino-acid nuclear and cytoplasmic protein that facilitates the assembly of histone H2A-H2B dimers into nucleosomes. NAP1L4 acts as a molecular chaperone that prevents non-specific aggregation of histones, ensuring their proper deposition onto DNA. It also participates in transcriptional activation by assisting chromatin remodeling complexes in regulating nucleosome dynamics near promoters and enhancers.
The NAP1L4 gene is located on chromosome 11p15.4 and encodes a ubiquitously expressed protein found in dividing and differentiating cells. NAP1L4 associates with cell cycle regulators and transcription factors to coordinate chromatin accessibility and gene expression. Its function is particularly important during embryogenesis, where rapid chromatin remodeling supports differentiation and proliferation. In somatic cells, NAP1L4 contributes to DNA damage response and maintenance of chromatin integrity.
Beyond histone assembly, NAP1L4 interacts with key signaling molecules and nuclear export proteins, linking chromatin organization to gene regulatory networks. Dysregulation of NAP1L4 expression has been observed in several cancers and developmental disorders, where altered nucleosome assembly can lead to epigenetic instability and aberrant transcription. Reduced NAP1L4 function has been associated with growth defects and impaired cell cycle progression in experimental models.
NAP1L4 antibody is widely used in chromatin biology, transcriptional regulation, and cancer research. It is suitable for immunoblotting, immunoprecipitation, and immunofluorescence to detect NAP1L4 localization and expression. This antibody supports studies of histone dynamics, chromatin assembly, and gene regulation. In developmental research, it aids in exploring chromatin organization during early embryonic differentiation.
Structurally, NAP1L4 contains acidic regions that bind histones electrostatically and domains that facilitate dimerization and complex formation. Its activity is regulated by phosphorylation and nuclear-cytoplasmic transport. NSJ Bioreagents provides NAP1L4 antibody reagents validated for use in chromatin remodeling, transcriptional control, and epigenetic regulation research. -
UniProt
- Q99733
抗原
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