SPRY2 抗体 (AA 1-315)
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Quick Overview for SPRY2 抗体 (AA 1-315) (ABIN7869184)
抗原
See all SPRY2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-315
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原理
- SPRY2 Antibody / Sprouty 2
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纯化方法
- Affinity purified
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免疫原
- Recombinant human protein (amino acids M1-T315) was used as the immunogen for the SPRY2 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the SPRY2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SPRY2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SPRY2 (Sprouty Homolog 2 (SPRY2))
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别名
- SPRY2
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背景
- Sprouty homolog 2 (Drosophila), also known as SPRY2, is a protein which in humans is encoded by the SPRY2 gene. It is mapped to 13q31.1. This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
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UniProt
- O43597
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途径
- EGFR Signaling Pathway, Sensory Perception of Sound, EGFR Downregulation
抗原
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