NEK7 抗体 (AA 1-302)
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北京 101111
Quick Overview for NEK7 抗体 (AA 1-302) (ABIN7869166)
抗原
See all NEK7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-302
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原理
- NEK7 Antibody / NIMA related kinase 7
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human NEK7 recombinant protein (Position: M1-S302) was used as the immunogen for the NEK7 antibody.
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亚型
- IgG
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anti-NEK7 (NEK7) (N-Term) antibody
NEK7 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, Pig, 猴, Bat, 小鸡, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NEK7 (NEK7) antibodyKD Validated NEK7 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2885 unconjugated Recombinant Antibody
anti-NEK7 (NEK7) (AA 1-30), (N-Term) antibodyNEK7 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB2967-2968 unconjugated
anti-NEK7 (NEK7) (AA 1-302) antibodyNEK7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-NEK7 (NEK7) (Internal Region) antibodyVerified NEK7 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-NEK7 (NEK7) (Internal Region) antibodyNEK7 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-NEK7 (NEK7) (Kinase Domain) antibodyNEK7 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NEK7 (NEK7) antibodyNEK7 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-NEK7 (NEK7) (AA 274-286) antibodyVerified NEK7 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-NEK7 (NEK7) (AA 1-50) antibodyNEK7 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the NEK7 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the NEK7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- NEK7
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别名
- NEK7
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背景
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NEK7 antibody detects NIMA related kinase 7, encoded by the NEK7 gene. NIMA related kinase 7 is a serine/threonine protein kinase belonging to the NIMA related kinase family, which plays important roles in mitotic progression, spindle assembly, and cytokinesis. NEK7 antibody provides researchers with a specific reagent for studying cell cycle regulation, mitotic control, and disease processes associated with abnormal kinase activity.
NIMA related kinase 7 is expressed in proliferating tissues and localizes to the centrosome during mitosis. Research using NEK7 antibody has shown that it regulates microtubule organization, spindle formation, and chromosome segregation. By phosphorylating structural and regulatory proteins, NEK7 ensures orderly mitotic progression and completion of cytokinesis.
Studies with NEK7 antibody have also revealed a role in inflammasome activation. NEK7 interacts with NLRP3 and is essential for assembly of the NLRP3 inflammasome, which mediates caspase-1 activation and interleukin-1 beta processing. This discovery links NEK7 to innate immunity and inflammation, broadening its functional scope beyond mitosis.
Dysregulation of NEK7 has been implicated in cancer and inflammatory disease. Research using NEK7 antibody has shown that overexpression promotes proliferation and survival in certain cancers, while loss-of-function impairs mitotic fidelity and contributes to chromosomal instability. In immune contexts, defective NEK7 regulation disrupts inflammasome activity, contributing to autoinflammatory syndromes.
NEK7 antibody is commonly used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies kinase levels in proliferative tissues, immunohistochemistry highlights centrosomal and tumor expression, and immunofluorescence reveals dynamic localization during mitosis. These applications make NEK7 antibody indispensable for cell cycle and inflammation research.
By providing validated NEK7 antibody reagents, NSJ Bioreagents supports studies into mitosis, innate immunity, and cancer biology. Detection of NIMA related kinase 7 provides researchers with insight into how kinases regulate both cell division and immune signaling. -
UniProt
- Q8TDX7
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途径
- Inflammasome
抗原
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