Syntaxin 16 抗体 (AA 1-301)
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Quick Overview for Syntaxin 16 抗体 (AA 1-301) (ABIN7869165)
抗原
See all Syntaxin 16 (STX16) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-301
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原理
- STX16 Antibody / Syntaxin 16
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human Syntaxin 16/STX16 recombinant protein (Position: M1-K301) was used as the immunogen for the STX16 antibody.
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亚型
- IgG
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anti-Syntaxin 16 (STX16) (AA 1-302) antibody
STX16 适用: 人, 小鼠, 大鼠, 兔, Hamster WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin 16 (STX16) antibodySTX16 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Syntaxin 16 (STX16) antibodyKD Validated STX16 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB4655 unconjugated Recombinant Antibody
anti-Syntaxin 16 (STX16) antibodySTX16 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin 16 (STX16) (AA 1-99) antibodySTX16 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D12 unconjugated
anti-Syntaxin 16 (STX16) (N-Term) antibodySTX16 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin 16 (STX16) (AA 1-300) antibodySTX16 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin 16 (STX16) (AA 247-274), (C-Term) antibodySTX16 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB32221 unconjugated
anti-Syntaxin 16 (STX16) (AA 1-304) antibodySTX16 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Syntaxin 16 (STX16) (AA 1-302) antibodySTX16 适用: 人, 小鼠, 大鼠, Hamster WB, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the STX16 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the STX16 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Syntaxin 16 (STX16)
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别名
- STX16
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背景
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STX16 antibody detects Syntaxin 16, encoded by the STX16 gene. Syntaxin 16 is a member of the SNARE family of proteins that regulate vesicle trafficking, membrane fusion, and intracellular transport. STX16 antibody provides researchers with a specific reagent for studying Golgi and endosomal transport, protein sorting, and cellular homeostasis.
Syntaxin 16 is a membrane-anchored protein localized primarily to the Golgi apparatus and endosomal compartments. Research using STX16 antibody has shown that it forms SNARE complexes with vesicle associated membrane proteins and SNAP proteins, enabling membrane fusion during trafficking. This function is essential for recycling receptors, delivering enzymes, and maintaining compartment identity.
Studies with STX16 antibody have revealed that Syntaxin 16 is critical for retrograde transport from endosomes to the Golgi. By interacting with the retromer complex and cargo adaptors, it ensures retrieval of proteins such as the cation independent mannose-6-phosphate receptor. This pathway maintains lysosomal enzyme delivery and Golgi organization, demonstrating the importance of STX16 in vesicle logistics.
Dysfunction of Syntaxin 16 has been implicated in disease. Research using STX16 antibody has shown that chromosomal rearrangements near the STX16 gene contribute to pseudohypoparathyroidism type 1b, a metabolic disorder characterized by abnormal imprinting and hormone resistance. Altered expression of STX16 has also been observed in cancer and neurodegenerative conditions, linking vesicle transport to disease mechanisms.
Syntaxin 16 is further implicated in glucose metabolism. Studies with STX16 antibody have demonstrated that it participates in trafficking of glucose transporters, affecting insulin responsive glucose uptake. This places Syntaxin 16 within networks connecting vesicle trafficking with metabolic regulation, emphasizing its diverse cellular roles.
STX16 antibody is widely used in western blotting, immunofluorescence, and immunohistochemistry. Western blotting quantifies expression and isoform diversity, immunofluorescence demonstrates Golgi localization and co-localization with trafficking machinery, and immunohistochemistry reveals tissue-specific expression. These applications make STX16 antibody indispensable in vesicle transport research.
By supplying validated STX16 antibody reagents, NSJ Bioreagents supports studies into vesicle fusion, Golgi biology, and disease. Detection of Syntaxin 16 provides insights into how SNARE proteins regulate trafficking pathways and maintain homeostasis. -
UniProt
- O14662
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途径
- Synaptic Vesicle Exocytosis
抗原
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