Syntaxin 4 抗体 (AA 1-278)
Our Local Distributor
北京 101111
Quick Overview for Syntaxin 4 抗体 (AA 1-278) (ABIN7869039)
抗原
See all Syntaxin 4 (STX4) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-278
-
原理
- STX4 Antibody / Syntaxin 4
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived human Syntaxin 4/STX4 recombinant protein (Position: M1-I278) was used as the immunogen for the STX4 antibody.
-
亚型
- IgG
-
-
anti-Syntaxin 4 (STX4) (AA 19-119) antibody
STX4 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6A1 unconjugated
anti-Syntaxin 4 (STX4) (AA 1-297) antibodySTX4 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin 4 (STX4) antibodySTX4 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Syntaxin 4 (STX4) antibodyKD Validated STX4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3340 unconjugated Recombinant Antibody
anti-Syntaxin 4 (STX4) (AA 1-297) antibodySTX4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Syntaxin 4 (STX4) (AA 101-150) antibodySTX4 适用: 人, 大鼠, 小鼠, Cow, Pig, 兔, 猴, 马, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin 4 (STX4) (C-Term) antibodySTX4 适用: 人, Cow, Pig, 兔, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin 4 (STX4) (AA 1-273) antibodySTX4 适用: 大鼠, 小鼠 WB, IP, ICC 宿主: 小鼠 Monoclonal 139-2 unconjugated
anti-Syntaxin 4 (STX4) (AA 1-273) antibodySTX4 适用: 人, 大鼠, 小鼠, Hamster WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin 4 (STX4) (C-Term) antibodySTX4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the STX4 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the STX4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- Syntaxin 4 (STX4)
-
别名
- STX4
-
背景
-
STX4 antibody detects Syntaxin 4, a membrane-anchored SNARE protein that mediates vesicle fusion and exocytosis at the plasma membrane. Encoded by the STX4 gene on chromosome 16p11.2, this t-SNARE protein participates in vesicular trafficking pathways, particularly in insulin-stimulated glucose transporter translocation, neurotransmitter release, and immune cell secretion. Syntaxin 4 plays a central role in membrane docking and fusion by forming SNARE complexes with SNAP23 and VAMP2 or VAMP3.
Structurally, Syntaxin 4 is a 273-amino-acid membrane protein of approximately 33 kilodaltons containing a C-terminal transmembrane anchor, a SNARE motif required for complex formation, and an N-terminal regulatory domain. It localizes to the plasma membrane and cytoplasmic vesicles in diverse tissues including adipose, neuronal, and epithelial cells. Upon stimulation, Syntaxin 4 assembles into heterotrimeric SNARE complexes that catalyze the fusion of transport vesicles with target membranes.
The STX4 antibody is widely used in cell biology, metabolism, and neurophysiology research to study vesicular trafficking, membrane fusion, and regulated exocytosis. Western blot analysis detects a 33 kilodalton band corresponding to Syntaxin 4, while immunofluorescence reveals peripheral and punctate membrane staining. This antibody provides a reliable reagent for analyzing vesicle dynamics and fusion machinery in secretory systems.
Functionally, Syntaxin 4 is essential for insulin-dependent GLUT4 trafficking in adipocytes and muscle cells, linking it to glucose uptake and metabolic homeostasis. It also contributes to immune cell secretion of cytokines and cytotoxic granules, as well as neurotransmitter release in the nervous system. Disruption of STX4 impairs exocytic processes and contributes to metabolic disorders such as type 2 diabetes. The STX4 antibody supports studies exploring SNARE-mediated exocytosis, vesicle targeting, and signal-dependent membrane fusion. NSJ Bioreagents validates this antibody for its applications, ensuring accuracy and reproducibility in vesicular transport studies. -
UniProt
- Q12846
-
途径
- Synaptic Vesicle Exocytosis
抗原
-
