MYOD1 抗体 (AA 1-275)
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Quick Overview for MYOD1 抗体 (AA 1-275) (ABIN7869031)
抗原
See all MYOD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-275
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原理
- Zebrafish Myod1 Antibody / Myoblast determination protein 1 / Myogenic factor 1
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Myod1 recombinant protein (amino acids M1-L275) was used as the immunogen for the Zebrafish Myod1 antibody.
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亚型
- Ig Fraction
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anti-Myogenic Differentiation 1 (MYOD1) (AA 150-250) antibody
MYOD1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Myogenic Differentiation 1 (MYOD1) (AA 51-150) antibodyMYOD1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Myogenic Differentiation 1 (MYOD1) antibodyMYOD1 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal rMYD712 unconjugated Recombinant Antibody
anti-Myogenic Differentiation 1 (MYOD1) antibodyMYOD1 适用: 人, 小鼠, 大鼠, 豚鼠, Hamster, 兔 WB, IHC 宿主: 兔 Monoclonal MYOD1-2075R unconjugated Recombinant Antibody
anti-Myogenic Differentiation 1 (MYOD1) (AA 1-320) antibodyMYOD1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myogenic Differentiation 1 (MYOD1) (AA 211-240) antibodyMYOD1 适用: 人 WB, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Myogenic Differentiation 1 (MYOD1) (AA 211-320) antibodyMYOD1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Myogenic Differentiation 1 (MYOD1) (AA 211-320) antibodyMYOD1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A7 unconjugated
anti-Myogenic Differentiation 1 (MYOD1) antibodyMYOD1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-Myogenic Differentiation 1 (MYOD1) (AA 211-240) antibodyMYOD1 适用: 人 WB, IF 宿主: 兔 Polyclonal RB18817 unconjugated
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应用备注
- Optimal dilution of the Zebrafish Myod1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Myod1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MYOD1 (Myogenic Differentiation 1 (MYOD1))
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别名
- Myod1
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背景
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Myod1, also called Myogenic factor 1, Myogenic differentiation 1 and Myoblast determination protein 1, is a master regulatory transcription factor that plays a central role in the specification and differentiation of skeletal muscle. In zebrafish, Myod1 is essential for the commitment of precursor cells to the myogenic lineage during embryonic development and regeneration. It acts by activating the expression of muscle specific genes and by coordinating the transition from cell proliferation to terminal differentiation.
Zebrafish Myod1 is the functional ortholog of human MYOD1. Both proteins belong to the basic helix loop helix family of transcription factors and share a high degree of sequence and functional conservation. Like its human counterpart, zebrafish Myod1 binds to E box elements in the promoters of muscle genes to drive their expression.
During zebrafish development, Myod1 is expressed in the somites and presomitic mesoderm, where it promotes the formation of fast twitch muscle fibers. It works in concert with other myogenic regulators such as Myf5 and Myogenin to establish the muscle differentiation program. Disruption of Myod1 function in zebrafish leads to defects in muscle formation and delayed differentiation of myoblasts.
Because of its conserved role in vertebrate myogenesis, zebrafish Myod1 is widely used as a marker of muscle lineage commitment and as a tool in genetic and chemical screening to study muscle development, regeneration, and disease. It also provides a useful model for understanding the regulation of transcriptional networks in myogenic cells.
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UniProt
- Q90477
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途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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